Cardiovascular health and subclinical atherosclerosis in second generation South Asian Americans: The MASALA study

Nilay S. Shah*, Juned Siddique, Mark D. Huffman, Alka M. Kanaya, Namratha R. Kandula

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We describe cardiovascular health (CVH) in second-generation (U.S.-born) South Asian Americans in the MASALA study, a population for whom CVH is not previously described. CVH factors in second-generation (N = 21) compared with first-generation (N = 495) South Asian Americans included: total cholesterol (199 ± 31 versus 191 ± 35 mg/dL, p = 0.25), low-density lipoprotein cholesterol (121 ± 27 versus 115 ± 30 mg/dL, p = 0.41), triglycerides (163 ± 197 versus 138 ± 72 mg/dL, p = 0.10), diet score (66 ± 8 versus 70 ± 6 points, p = 0.06), BMI (27.6 ± 4.9 versus 26.2 ± 4.1 kg/m2, p = 0.12), and CAC prevalence (26.3% versus 23.9%, p = 0.34). Age- and sex-adjusted differences were not statistically significant. Further investigation of CVH in this risk-enhanced population may help identify differences between second-generation and first-generation immigrant South Asians in the U.S.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalIndian Heart Journal
Volume73
Issue number5
DOIs
StatePublished - Sep 1 2021

Funding

The project described was supported by grant numbers R01HL093009 and F32HL149187 from the National Heart, Lung, and Blood Institute , and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health , through UCSF- CTSI grant numbers UL1RR024131 and UL1TR001872 and the Northwestern University Clinical and Translational Sciences Institute grant number UL1TR001422 . The sponsors were not involved in study design, data collection, or preparation of this manuscript. This research was approved by the Institutional Review Board at Northwestern University ( #STU00019837 ) and University of California–San Francisco ( #10–00353 ). Dr. Huffman reports grants from American Heart Association, Verily, AstraZeneca, and Boehringer Ingelheim and personal fees from American Medical Association, all unrelated to the submitted work. The George Institute for Global Health has a patent, license, and has received investment funding with intent to commercialize fixed-dose combination therapy through its social enterprise business, George Medicines. No financial disclosures were reported by other authors of this paper.The project described was supported by grant numbers R01HL093009 and F32HL149187 from the National Heart, Lung, and Blood Institute, and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI grant numbers UL1RR024131 and UL1TR001872 and the Northwestern University Clinical and Translational Sciences Institute grant number UL1TR001422. The sponsors were not involved in study design, data collection, or preparation of this manuscript. This research was approved by the Institutional Review Board at Northwestern University (#STU00019837) and University of California?San Francisco (#10?00353). Dr. Huffman reports grants from American Heart Association , Verily, AstraZeneca , and Boehringer Ingelheim and personal fees from American Medical Association , all unrelated to the submitted work. The George Institute for Global Health has a patent, license, and has received investment funding with intent to commercialize fixed-dose combination therapy through its social enterprise business, George Medicines. No financial disclosures were reported by other authors of this paper.

Keywords

  • Cardiovascular risk factors
  • Second generation
  • South Asian Americans

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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