Carotid arterial wall MRI at 3T using 3D variable-flip-angle turbo spin-echo (TSE) with flow-sensitive dephasing (FSD)

Zhaoyang Fan, Zhuoli Zhang, Yiu Cho Chung, Peter Weale, Sven Zuehlsdorff, James Carr, Debiao Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Purpose: To evaluate the effectiveness of flow-sensitive dephasing (FSD) magnetization preparation in improving blood signal suppression of three-dimensional (3D) turbo spin-echo (TSE) sequence (SPACE) for isotropic high-spatial-resolution carotid arterial wall imaging at 3T. Materials and Methods: The FSD-prepared SPACE sequence (FSD-SPACE) was implemented by adding two identical FSD gradient pulses right before and after the first refocusing 180°-pulse of the SPACE sequence in all three orthogonal directions. Nine healthy volunteers were imaged at 3T with SPACE, FSD-SPACE, and multislice T2-weighted 2D TSE coupled with saturation band (SB-TSE). Apparent carotid wall-lumen contrast-to-noise ratio (aCNRw-1) and apparent lumen area (aLA) at the locations with residualblood (rb) signal shown on SPACE images were compared between SPACE and FSD-SPACE. Carotid aCNRw-1 and lumen (LA) and wall area (WA) measured from FSD-SPACE were compared to those measured from SB-TSE. Results: Plaque-mimicking flow artifacts identified in seven carotids on SPACE images were eliminated on FSDSPACE images. The FSD preparation resulted in slightly reduced aCNRw-1 (P = 0.025), but significantly improved aCNR between the wall and rb regions (P < 0.001) and larger aLA (P < 0.001). Compared to SB-TSE, FSD-SPACE offered comparable aCNRw-1 with much higher spatial resolution, shorter imaging time, and larger artery coverage. The LA and WA measurements from the two techniques were in good agreement based on intraclasss correlation coefficient (0.988 and 0.949, respectively; P < 0.001) and Bland-Altman analyses. Conclusion: FSD-SPACE is a time-efficient 3D imaging technique for carotid arterial wall with superior spatial resolution and blood signal suppression.

Original languageEnglish (US)
Pages (from-to)645-654
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number3
StatePublished - Mar 2010


  • 3D SPACE
  • Atherosclerosis
  • Black-blood
  • Carotid artery
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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