Carotid bodies in sudden infant death syndrome: A combined light microscopic, ultrastructural, and biochemical study

Ernest E. Lack*, Antonio R. Perez-Atayde, James B. Young

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Carotid bodies (CBs) are peripheral chemoreceptors that can undergo compensatory hypertrophy and hyperplasia in some patients with chronic hypoxemia. At the Children's Hospital morphometric and biochemical analyses were done on CBs obtained at autopsy from 89 infants in the first year of life to determine if there were statistically significant differences in sudden infant death syndrome (SIDS, n == 38) compared with an age-matched control population (n == 51). Mean combined weights of CBs from SIDS victims were greater than controls in the 1-to 4-month age interval (mean == 3.4 mg, p < 0.075) and the 4- to 8-month interval (mean == 5.0 mg, p < 0.098) but the differences were not statistically significant (t-test, p < 0.05). Computerized planimetry of total surface area and area occupied by "functioned" parenchyma revealed no statistically significant differences. Both groups showed an equally intense degree oj cytoplasmic argyrophilia of chief cells, and electron microscopy of CBs from 5 SIDS victims was indistinguishable from controls, including overall content of dense-core neurosecretory granules. There were also no significant differences in catecholamine content using liquid chromatography with electrochemical detection (SIDS n == 29, controls n == 21). These morphometric, ultrastructural, and biochemical data are not supportive for CBs having a significant role in the pathogenesis or etiology of SIDS..

Original languageEnglish (US)
Pages (from-to)335-350
Number of pages16
JournalFetal and Pediatric Pathology
Volume6
Issue number2-3
DOIs
StatePublished - Jan 1 1986

Keywords

  • Carotid bodies
  • Chemoreceptor
  • SIDS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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