Carpal tunnel syndrome associated with the use of aromatase inhibitors in breast cancer

Taiga Nishihori, Jaehyuk Choi, Michael P. DiGiovanna, J. Grant Thomson, Peter C. Kohler, Joanne McGurn, Gina G. Chung*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aromatase inhibitors (AI) inhibit peripheral conversion of androgens to estradiol and are commonly used as hormonal therapy for postmenopausal women with hormone receptor-positive breast cancer in the metastatic and adjuvant settings. Joint-related symptoms, however, are seen in a significant proportion of patients. Carpal tunnel syndrome (CTS) is a common nerve entrapment disorder affecting the median nerve. We describe 6 patients with newly diagnosed CTS after initiation of adjuvant AI therapy. Aromatase inhibitors were discontinued in several patients secondary to this toxicity with some switching to tamoxifen and most subsequently experiencing relief of their symptoms. Potential pathophysiologic roles of hormonal manipulation with AIs and other risk factors that might contribute to CTS are discussed. Aromatase inhibitors might accentuate the occurrence of CTS and potentially other nerve entrapment syndromes, and a more systematic approach should be used to better understand the clinical significance and incidence of these symptoms.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalClinical Breast Cancer
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2008

Fingerprint

Aromatase Inhibitors
Carpal Tunnel Syndrome
Breast Neoplasms
Nerve Compression Syndromes
Median Nerve
Tamoxifen
Androgens
Estradiol
Joints
Hormones
Incidence
Therapeutics

Keywords

  • Adjuvant therapy
  • Estrogen receptor
  • Paresthesia
  • Sentinel lymph node dissection

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nishihori, T., Choi, J., DiGiovanna, M. P., Thomson, J. G., Kohler, P. C., McGurn, J., & Chung, G. G. (2008). Carpal tunnel syndrome associated with the use of aromatase inhibitors in breast cancer. Clinical Breast Cancer, 8(4), 362-365. https://doi.org/10.3816/CBC.2008.n.043
Nishihori, Taiga ; Choi, Jaehyuk ; DiGiovanna, Michael P. ; Thomson, J. Grant ; Kohler, Peter C. ; McGurn, Joanne ; Chung, Gina G. / Carpal tunnel syndrome associated with the use of aromatase inhibitors in breast cancer. In: Clinical Breast Cancer. 2008 ; Vol. 8, No. 4. pp. 362-365.
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Nishihori, T, Choi, J, DiGiovanna, MP, Thomson, JG, Kohler, PC, McGurn, J & Chung, GG 2008, 'Carpal tunnel syndrome associated with the use of aromatase inhibitors in breast cancer', Clinical Breast Cancer, vol. 8, no. 4, pp. 362-365. https://doi.org/10.3816/CBC.2008.n.043

Carpal tunnel syndrome associated with the use of aromatase inhibitors in breast cancer. / Nishihori, Taiga; Choi, Jaehyuk; DiGiovanna, Michael P.; Thomson, J. Grant; Kohler, Peter C.; McGurn, Joanne; Chung, Gina G.

In: Clinical Breast Cancer, Vol. 8, No. 4, 01.01.2008, p. 362-365.

Research output: Contribution to journalArticle

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