Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features

Asha Singanamalli*, Haibo Wang, Anant Madabhushi, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford Jack, William Jagust, John Trojanowki, Arthur Toga, Laurel Beckett, Robert Green, Andrew Saykin, John Morris, Leslie Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina CarterSara Dolen, Lon Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith Heidebrink, Joanne Lord, Sara Mason, Colleen Albers, David Knopman, Kris Johnson, Rachelle Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence Honig, Karen Bell, Beau Ances, Maria Carroll, Mary Creech, Erin Franklin, Mark Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj Shah, Leyla Detoledo-Morrell, Ranjan Duara, Daniel Varon, Maria Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, James Galvin, Brittany Cerbone, Christina Michel, Dana Pogorelec, Henry Rusinek, Mony De Leon, Lidia Glodzik, Susan De Santi, P. Doraiswamy, Jeffrey Petrella, Salvador Borges-Neto, Terence Wong, Edward Coleman, Charles Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton Porsteinsson, Bonnie Goldstein, Kim Martin, Kelly Makino, M. Ismail, Connie Brand, Ruth Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan Levey, James Lah, Janet Cellar, Jeffrey Burns, Russell Swerdlow, William Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po Lu, George Bartzokis, Neill Graff-Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin Farlow, Ann Marie Hake, Brandy Matthews, Jared Brosch, Scott Herring, Cynthia Hunt, Christopher Dyck, Richard Carson, Martha MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa Sperling, Keith Johnson, Gad Marshall, Jerome Yesavage, Joy Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan Sabbagh, Christine Belden, Sandra Jacobson, Sherye Sirrel, Neil Kowall, Ronald Killiany, Andrew Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles Decarli, Owen Carmichael, Smita Kittur, Michael Borrie, T. Y. Lee, Robbartha, Sterling Johnson, Sanjay Asthana, Cynthia Carlsson, Steven Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Nadira Trncic, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas Scharre, Maria Kataki, Anahita Adeli, Earl Zimmerman, Dzintra Celmins, Alice Brown, Godfrey Pearlson, Karen Blank, Karen Anderson, Laura Flashman, Marc Seltzer, Mary Hynes, Robert Santulli, Kaycee Sink, Leslie Gordineer, Jeff Williamson, Pradeep Garg, Franklin Watkins, Brian Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard Rosen, Bruce Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, previous studies have attempted to develop fused predictors of AD and MCI. These studies have two main limitations. Most do not simultaneously consider all diagnostic categories and provide suboptimal fused representations using the same set of modalities for prediction of all classes. In this work, we present a combined framework, cascaded multiview canonical correlation (CaMCCo), for fusion and cascaded classification that incorporates all diagnostic categories and optimizes classification by selectively combining a subset of modalities at each level of the cascade. CaMCCo is evaluated on a data cohort comprising 149 patients for whom neurophysiological, neuroimaging, proteomic and genomic data were available. Results suggest that fusion of select modalities for each classification task outperforms (mean AUC = 0.92) fusion of all modalities (mean AUC = 0.54) and individual modalities (mean AUC = 0.90, 0.53, 0.71, 0.73, 0.62, 0.68). In addition, CaMCCo outperforms all other multi-class classification methods for MCI prediction (PPV: 0.80 vs. 0.67, 0.63).

Original languageEnglish (US)
Article number8137
JournalScientific reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

Early Diagnosis
Alzheimer Disease
Area Under Curve
Neuroimaging
Proteomics
Cognitive Dysfunction

ASJC Scopus subject areas

  • General

Cite this

Singanamalli, Asha ; Wang, Haibo ; Madabhushi, Anant ; Weiner, Michael ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford ; Jagust, William ; Trojanowki, John ; Toga, Arthur ; Beckett, Laurel ; Green, Robert ; Saykin, Andrew ; Morris, John ; Shaw, Leslie ; Kaye, Jeffrey ; Quinn, Joseph ; Silbert, Lisa ; Lind, Betty ; Carter, Raina ; Dolen, Sara ; Schneider, Lon ; Pawluczyk, Sonia ; Beccera, Mauricio ; Teodoro, Liberty ; Spann, Bryan ; Brewer, James ; Vanderswag, Helen ; Fleisher, Adam ; Heidebrink, Judith ; Lord, Joanne ; Mason, Sara ; Albers, Colleen ; Knopman, David ; Johnson, Kris ; Doody, Rachelle ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Rountree, Susan ; Dang, Mimi ; Stern, Yaakov ; Honig, Lawrence ; Bell, Karen ; Ances, Beau ; Carroll, Maria ; Creech, Mary ; Franklin, Erin ; Mintun, Mark ; Schneider, Stacy ; Oliver, Angela ; Marson, Daniel ; Griffith, Randall ; Clark, David ; Geldmacher, David ; Brockington, John ; Roberson, Erik ; Natelson Love, Marissa ; Grossman, Hillel ; Mitsis, Effie ; Shah, Raj ; Detoledo-Morrell, Leyla ; Duara, Ranjan ; Varon, Daniel ; Greig, Maria ; Roberts, Peggy ; Albert, Marilyn ; Onyike, Chiadi ; D'Agostino, Daniel ; Kielb, Stephanie ; Galvin, James ; Cerbone, Brittany ; Michel, Christina ; Pogorelec, Dana ; Rusinek, Henry ; De Leon, Mony ; Glodzik, Lidia ; De Santi, Susan ; Doraiswamy, P. ; Petrella, Jeffrey ; Borges-Neto, Salvador ; Wong, Terence ; Coleman, Edward ; Smith, Charles ; Jicha, Greg ; Hardy, Peter ; Sinha, Partha ; Oates, Elizabeth ; Conrad, Gary ; Porsteinsson, Anton ; Goldstein, Bonnie ; Martin, Kim ; Makino, Kelly ; Ismail, M. ; Brand, Connie ; Mulnard, Ruth ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Womack, Kyle ; Mathews, Dana ; Quiceno, Mary ; Levey, Allan ; Lah, James ; Cellar, Janet ; Burns, Jeffrey ; Swerdlow, Russell ; Brooks, William ; Apostolova, Liana ; Tingus, Kathleen ; Woo, Ellen ; Silverman, Daniel ; Lu, Po ; Bartzokis, George ; Graff-Radford, Neill ; Parfitt, Francine ; Kendall, Tracy ; Johnson, Heather ; Farlow, Martin ; Marie Hake, Ann ; Matthews, Brandy ; Brosch, Jared ; Herring, Scott ; Hunt, Cynthia ; Dyck, Christopher ; Carson, Richard ; MacAvoy, Martha ; Varma, Pradeep ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Stefanovic, Bojana ; Caldwell, Curtis ; Robin Hsiung, Ging Yuek ; Feldman, Howard ; Mudge, Benita ; Assaly, Michele ; Finger, Elizabeth ; Pasternack, Stephen ; Rachisky, Irina ; Trost, Dick ; Kertesz, Andrew ; Bernick, Charles ; Munic, Donna ; Mesulam, Marek Marsel ; Lipowski, Kristine ; Weintraub, Sandra ; Bonakdarpour, Borna ; Kerwin, Diana ; Wu, Chuang Kuo ; Johnson, Nancy ; Sadowsky, Carl ; Villena, Teresa ; Scott Turner, Raymond ; Johnson, Kathleen ; Reynolds, Brigid ; Sperling, Reisa ; Johnson, Keith ; Marshall, Gad ; Yesavage, Jerome ; Taylor, Joy ; Lane, Barton ; Rosen, Allyson ; Tinklenberg, Jared ; Sabbagh, Marwan ; Belden, Christine ; Jacobson, Sandra ; Sirrel, Sherye ; Kowall, Neil ; Killiany, Ronald ; Budson, Andrew ; Norbash, Alexander ; Lynn Johnson, Patricia ; Obisesan, Thomas ; Wolday, Saba ; Allard, Joanne ; Lerner, Alan ; Ogrocki, Paula ; Tatsuoka, Curtis ; Fatica, Parianne ; Fletcher, Evan ; Maillard, Pauline ; Olichney, John ; Decarli, Charles ; Carmichael, Owen ; Kittur, Smita ; Borrie, Michael ; Lee, T. Y. ; Robbartha ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia ; Potkin, Steven ; Preda, Adrian ; Nguyen, Dana ; Tariot, Pierre ; Burke, Anna ; Trncic, Nadira ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Scharre, Douglas ; Kataki, Maria ; Adeli, Anahita ; Zimmerman, Earl ; Celmins, Dzintra ; Brown, Alice ; Pearlson, Godfrey ; Blank, Karen ; Anderson, Karen ; Flashman, Laura ; Seltzer, Marc ; Hynes, Mary ; Santulli, Robert ; Sink, Kaycee ; Gordineer, Leslie ; Williamson, Jeff ; Garg, Pradeep ; Watkins, Franklin ; Ott, Brian ; Querfurth, Henry ; Tremont, Geoffrey ; Salloway, Stephen ; Malloy, Paul ; Correia, Stephen ; Rosen, Howard ; Miller, Bruce ; Perry, David ; Mintzer, Jacobo ; Spicer, Kenneth ; Bachman, David ; Pomara, Nunzio ; Hernando, Raymundo ; Sarrael, Antero ; Relkin, Norman ; Chaing, Gloria ; Lin, Michael ; Ravdin, Lisa ; Smith, Amanda ; Ashok Raj, Balebail ; Fargher, Kristin. / Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features. In: Scientific reports. 2017 ; Vol. 7, No. 1.
@article{f615225d2b7e4d379d37b897e681cc37,
title = "Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features",
abstract = "The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, previous studies have attempted to develop fused predictors of AD and MCI. These studies have two main limitations. Most do not simultaneously consider all diagnostic categories and provide suboptimal fused representations using the same set of modalities for prediction of all classes. In this work, we present a combined framework, cascaded multiview canonical correlation (CaMCCo), for fusion and cascaded classification that incorporates all diagnostic categories and optimizes classification by selectively combining a subset of modalities at each level of the cascade. CaMCCo is evaluated on a data cohort comprising 149 patients for whom neurophysiological, neuroimaging, proteomic and genomic data were available. Results suggest that fusion of select modalities for each classification task outperforms (mean AUC = 0.92) fusion of all modalities (mean AUC = 0.54) and individual modalities (mean AUC = 0.90, 0.53, 0.71, 0.73, 0.62, 0.68). In addition, CaMCCo outperforms all other multi-class classification methods for MCI prediction (PPV: 0.80 vs. 0.67, 0.63).",
author = "Asha Singanamalli and Haibo Wang and Anant Madabhushi and Michael Weiner and Paul Aisen and Ronald Petersen and Clifford Jack and William Jagust and John Trojanowki and Arthur Toga and Laurel Beckett and Robert Green and Andrew Saykin and John Morris and Leslie Shaw and Jeffrey Kaye and Joseph Quinn and Lisa Silbert and Betty Lind and Raina Carter and Sara Dolen and Lon Schneider and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Bryan Spann and James Brewer and Helen Vanderswag and Adam Fleisher and Judith Heidebrink and Joanne Lord and Sara Mason and Colleen Albers and David Knopman and Kris Johnson and Rachelle Doody and Javier Villanueva-Meyer and Munir Chowdhury and Susan Rountree and Mimi Dang and Yaakov Stern and Lawrence Honig and Karen Bell and Beau Ances and Maria Carroll and Mary Creech and Erin Franklin and Mark Mintun and Stacy Schneider and Angela Oliver and Daniel Marson and Randall Griffith and David Clark and David Geldmacher and John Brockington and Erik Roberson and {Natelson Love}, Marissa and Hillel Grossman and Effie Mitsis and Raj Shah and Leyla Detoledo-Morrell and Ranjan Duara and Daniel Varon and Maria Greig and Peggy Roberts and Marilyn Albert and Chiadi Onyike and Daniel D'Agostino and Stephanie Kielb and James Galvin and Brittany Cerbone and Christina Michel and Dana Pogorelec and Henry Rusinek and {De Leon}, Mony and Lidia Glodzik and {De Santi}, Susan and P. Doraiswamy and Jeffrey Petrella and Salvador Borges-Neto and Terence Wong and Edward Coleman and Charles Smith and Greg Jicha and Peter Hardy and Partha Sinha and Elizabeth Oates and Gary Conrad and Anton Porsteinsson and Bonnie Goldstein and Kim Martin and Kelly Makino and M. Ismail and Connie Brand and Ruth Mulnard and Gaby Thai and Catherine Mc-Adams-Ortiz and Kyle Womack and Dana Mathews and Mary Quiceno and Allan Levey and James Lah and Janet Cellar and Jeffrey Burns and Russell Swerdlow and William Brooks and Liana Apostolova and Kathleen Tingus and Ellen Woo and Daniel Silverman and Po Lu and George Bartzokis and Neill Graff-Radford and Francine Parfitt and Tracy Kendall and Heather Johnson and Martin Farlow and {Marie Hake}, Ann and Brandy Matthews and Jared Brosch and Scott Herring and Cynthia Hunt and Christopher Dyck and Richard Carson and Martha MacAvoy and Pradeep Varma and Howard Chertkow and Howard Bergman and Chris Hosein and Sandra Black and Bojana Stefanovic and Curtis Caldwell and {Robin Hsiung}, {Ging Yuek} and Howard Feldman and Benita Mudge and Michele Assaly and Elizabeth Finger and Stephen Pasternack and Irina Rachisky and Dick Trost and Andrew Kertesz and Charles Bernick and Donna Munic and Mesulam, {Marek Marsel} and Kristine Lipowski and Sandra Weintraub and Borna Bonakdarpour and Diana Kerwin and Wu, {Chuang Kuo} and Nancy Johnson and Carl Sadowsky and Teresa Villena and {Scott Turner}, Raymond and Kathleen Johnson and Brigid Reynolds and Reisa Sperling and Keith Johnson and Gad Marshall and Jerome Yesavage and Joy Taylor and Barton Lane and Allyson Rosen and Jared Tinklenberg and Marwan Sabbagh and Christine Belden and Sandra Jacobson and Sherye Sirrel and Neil Kowall and Ronald Killiany and Andrew Budson and Alexander Norbash and {Lynn Johnson}, Patricia and Thomas Obisesan and Saba Wolday and Joanne Allard and Alan Lerner and Paula Ogrocki and Curtis Tatsuoka and Parianne Fatica and Evan Fletcher and Pauline Maillard and John Olichney and Charles Decarli and Owen Carmichael and Smita Kittur and Michael Borrie and Lee, {T. Y.} and Robbartha and Sterling Johnson and Sanjay Asthana and Cynthia Carlsson and Steven Potkin and Adrian Preda and Dana Nguyen and Pierre Tariot and Anna Burke and Nadira Trncic and Stephanie Reeder and Vernice Bates and Horacio Capote and Michelle Rainka and Douglas Scharre and Maria Kataki and Anahita Adeli and Earl Zimmerman and Dzintra Celmins and Alice Brown and Godfrey Pearlson and Karen Blank and Karen Anderson and Laura Flashman and Marc Seltzer and Mary Hynes and Robert Santulli and Kaycee Sink and Leslie Gordineer and Jeff Williamson and Pradeep Garg and Franklin Watkins and Brian Ott and Henry Querfurth and Geoffrey Tremont and Stephen Salloway and Paul Malloy and Stephen Correia and Howard Rosen and Bruce Miller and David Perry and Jacobo Mintzer and Kenneth Spicer and David Bachman and Nunzio Pomara and Raymundo Hernando and Antero Sarrael and Norman Relkin and Gloria Chaing and Michael Lin and Lisa Ravdin and Amanda Smith and {Ashok Raj}, Balebail and Kristin Fargher",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41598-017-03925-0",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Singanamalli, A, Wang, H, Madabhushi, A, Weiner, M, Aisen, P, Petersen, R, Jack, C, Jagust, W, Trojanowki, J, Toga, A, Beckett, L, Green, R, Saykin, A, Morris, J, Shaw, L, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, L, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, B, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, J, Lord, J, Mason, S, Albers, C, Knopman, D, Johnson, K, Doody, R, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Bell, K, Ances, B, Carroll, M, Creech, M, Franklin, E, Mintun, M, Schneider, S, Oliver, A, Marson, D, Griffith, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Natelson Love, M, Grossman, H, Mitsis, E, Shah, R, Detoledo-Morrell, L, Duara, R, Varon, D, Greig, M, Roberts, P, Albert, M, Onyike, C, D'Agostino, D, Kielb, S, Galvin, J, Cerbone, B, Michel, C, Pogorelec, D, Rusinek, H, De Leon, M, Glodzik, L, De Santi, S, Doraiswamy, P, Petrella, J, Borges-Neto, S, Wong, T, Coleman, E, Smith, C, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Porsteinsson, A, Goldstein, B, Martin, K, Makino, K, Ismail, M, Brand, C, Mulnard, R, Thai, G, Mc-Adams-Ortiz, C, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Cellar, J, Burns, J, Swerdlow, R, Brooks, W, Apostolova, L, Tingus, K, Woo, E, Silverman, D, Lu, P, Bartzokis, G, Graff-Radford, N, Parfitt, F, Kendall, T, Johnson, H, Farlow, M, Marie Hake, A, Matthews, B, Brosch, J, Herring, S, Hunt, C, Dyck, C, Carson, R, MacAvoy, M, Varma, P, Chertkow, H, Bergman, H, Hosein, C, Black, S, Stefanovic, B, Caldwell, C, Robin Hsiung, GY, Feldman, H, Mudge, B, Assaly, M, Finger, E, Pasternack, S, Rachisky, I, Trost, D, Kertesz, A, Bernick, C, Munic, D, Mesulam, MM, Lipowski, K, Weintraub, S, Bonakdarpour, B, Kerwin, D, Wu, CK, Johnson, N, Sadowsky, C, Villena, T, Scott Turner, R, Johnson, K, Reynolds, B, Sperling, R, Johnson, K, Marshall, G, Yesavage, J, Taylor, J, Lane, B, Rosen, A, Tinklenberg, J, Sabbagh, M, Belden, C, Jacobson, S, Sirrel, S, Kowall, N, Killiany, R, Budson, A, Norbash, A, Lynn Johnson, P, Obisesan, T, Wolday, S, Allard, J, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Kittur, S, Borrie, M, Lee, TY, Robbartha, Johnson, S, Asthana, S, Carlsson, C, Potkin, S, Preda, A, Nguyen, D, Tariot, P, Burke, A, Trncic, N, Reeder, S, Bates, V, Capote, H, Rainka, M, Scharre, D, Kataki, M, Adeli, A, Zimmerman, E, Celmins, D, Brown, A, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Sink, K, Gordineer, L, Williamson, J, Garg, P, Watkins, F, Ott, B, Querfurth, H, Tremont, G, Salloway, S, Malloy, P, Correia, S, Rosen, H, Miller, B, Perry, D, Mintzer, J, Spicer, K, Bachman, D, Pomara, N, Hernando, R, Sarrael, A, Relkin, N, Chaing, G, Lin, M, Ravdin, L, Smith, A, Ashok Raj, B & Fargher, K 2017, 'Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features', Scientific reports, vol. 7, no. 1, 8137. https://doi.org/10.1038/s41598-017-03925-0

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features. / Singanamalli, Asha; Wang, Haibo; Madabhushi, Anant; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Clifford; Jagust, William; Trojanowki, John; Toga, Arthur; Beckett, Laurel; Green, Robert; Saykin, Andrew; Morris, John; Shaw, Leslie; Kaye, Jeffrey; Quinn, Joseph; Silbert, Lisa; Lind, Betty; Carter, Raina; Dolen, Sara; Schneider, Lon; Pawluczyk, Sonia; Beccera, Mauricio; Teodoro, Liberty; Spann, Bryan; Brewer, James; Vanderswag, Helen; Fleisher, Adam; Heidebrink, Judith; Lord, Joanne; Mason, Sara; Albers, Colleen; Knopman, David; Johnson, Kris; Doody, Rachelle; Villanueva-Meyer, Javier; Chowdhury, Munir; Rountree, Susan; Dang, Mimi; Stern, Yaakov; Honig, Lawrence; Bell, Karen; Ances, Beau; Carroll, Maria; Creech, Mary; Franklin, Erin; Mintun, Mark; Schneider, Stacy; Oliver, Angela; Marson, Daniel; Griffith, Randall; Clark, David; Geldmacher, David; Brockington, John; Roberson, Erik; Natelson Love, Marissa; Grossman, Hillel; Mitsis, Effie; Shah, Raj; Detoledo-Morrell, Leyla; Duara, Ranjan; Varon, Daniel; Greig, Maria; Roberts, Peggy; Albert, Marilyn; Onyike, Chiadi; D'Agostino, Daniel; Kielb, Stephanie; Galvin, James; Cerbone, Brittany; Michel, Christina; Pogorelec, Dana; Rusinek, Henry; De Leon, Mony; Glodzik, Lidia; De Santi, Susan; Doraiswamy, P.; Petrella, Jeffrey; Borges-Neto, Salvador; Wong, Terence; Coleman, Edward; Smith, Charles; Jicha, Greg; Hardy, Peter; Sinha, Partha; Oates, Elizabeth; Conrad, Gary; Porsteinsson, Anton; Goldstein, Bonnie; Martin, Kim; Makino, Kelly; Ismail, M.; Brand, Connie; Mulnard, Ruth; Thai, Gaby; Mc-Adams-Ortiz, Catherine; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Levey, Allan; Lah, James; Cellar, Janet; Burns, Jeffrey; Swerdlow, Russell; Brooks, William; Apostolova, Liana; Tingus, Kathleen; Woo, Ellen; Silverman, Daniel; Lu, Po; Bartzokis, George; Graff-Radford, Neill; Parfitt, Francine; Kendall, Tracy; Johnson, Heather; Farlow, Martin; Marie Hake, Ann; Matthews, Brandy; Brosch, Jared; Herring, Scott; Hunt, Cynthia; Dyck, Christopher; Carson, Richard; MacAvoy, Martha; Varma, Pradeep; Chertkow, Howard; Bergman, Howard; Hosein, Chris; Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Robin Hsiung, Ging Yuek; Feldman, Howard; Mudge, Benita; Assaly, Michele; Finger, Elizabeth; Pasternack, Stephen; Rachisky, Irina; Trost, Dick; Kertesz, Andrew; Bernick, Charles; Munic, Donna; Mesulam, Marek Marsel; Lipowski, Kristine; Weintraub, Sandra; Bonakdarpour, Borna; Kerwin, Diana; Wu, Chuang Kuo; Johnson, Nancy; Sadowsky, Carl; Villena, Teresa; Scott Turner, Raymond; Johnson, Kathleen; Reynolds, Brigid; Sperling, Reisa; Johnson, Keith; Marshall, Gad; Yesavage, Jerome; Taylor, Joy; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; Sabbagh, Marwan; Belden, Christine; Jacobson, Sandra; Sirrel, Sherye; Kowall, Neil; Killiany, Ronald; Budson, Andrew; Norbash, Alexander; Lynn Johnson, Patricia; Obisesan, Thomas; Wolday, Saba; Allard, Joanne; Lerner, Alan; Ogrocki, Paula; Tatsuoka, Curtis; Fatica, Parianne; Fletcher, Evan; Maillard, Pauline; Olichney, John; Decarli, Charles; Carmichael, Owen; Kittur, Smita; Borrie, Michael; Lee, T. Y.; Robbartha; Johnson, Sterling; Asthana, Sanjay; Carlsson, Cynthia; Potkin, Steven; Preda, Adrian; Nguyen, Dana; Tariot, Pierre; Burke, Anna; Trncic, Nadira; Reeder, Stephanie; Bates, Vernice; Capote, Horacio; Rainka, Michelle; Scharre, Douglas; Kataki, Maria; Adeli, Anahita; Zimmerman, Earl; Celmins, Dzintra; Brown, Alice; Pearlson, Godfrey; Blank, Karen; Anderson, Karen; Flashman, Laura; Seltzer, Marc; Hynes, Mary; Santulli, Robert; Sink, Kaycee; Gordineer, Leslie; Williamson, Jeff; Garg, Pradeep; Watkins, Franklin; Ott, Brian; Querfurth, Henry; Tremont, Geoffrey; Salloway, Stephen; Malloy, Paul; Correia, Stephen; Rosen, Howard; Miller, Bruce; Perry, David; Mintzer, Jacobo; Spicer, Kenneth; Bachman, David; Pomara, Nunzio; Hernando, Raymundo; Sarrael, Antero; Relkin, Norman; Chaing, Gloria; Lin, Michael; Ravdin, Lisa; Smith, Amanda; Ashok Raj, Balebail; Fargher, Kristin.

In: Scientific reports, Vol. 7, No. 1, 8137, 01.12.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features

AU - Singanamalli, Asha

AU - Wang, Haibo

AU - Madabhushi, Anant

AU - Weiner, Michael

AU - Aisen, Paul

AU - Petersen, Ronald

AU - Jack, Clifford

AU - Jagust, William

AU - Trojanowki, John

AU - Toga, Arthur

AU - Beckett, Laurel

AU - Green, Robert

AU - Saykin, Andrew

AU - Morris, John

AU - Shaw, Leslie

AU - Kaye, Jeffrey

AU - Quinn, Joseph

AU - Silbert, Lisa

AU - Lind, Betty

AU - Carter, Raina

AU - Dolen, Sara

AU - Schneider, Lon

AU - Pawluczyk, Sonia

AU - Beccera, Mauricio

AU - Teodoro, Liberty

AU - Spann, Bryan

AU - Brewer, James

AU - Vanderswag, Helen

AU - Fleisher, Adam

AU - Heidebrink, Judith

AU - Lord, Joanne

AU - Mason, Sara

AU - Albers, Colleen

AU - Knopman, David

AU - Johnson, Kris

AU - Doody, Rachelle

AU - Villanueva-Meyer, Javier

AU - Chowdhury, Munir

AU - Rountree, Susan

AU - Dang, Mimi

AU - Stern, Yaakov

AU - Honig, Lawrence

AU - Bell, Karen

AU - Ances, Beau

AU - Carroll, Maria

AU - Creech, Mary

AU - Franklin, Erin

AU - Mintun, Mark

AU - Schneider, Stacy

AU - Oliver, Angela

AU - Marson, Daniel

AU - Griffith, Randall

AU - Clark, David

AU - Geldmacher, David

AU - Brockington, John

AU - Roberson, Erik

AU - Natelson Love, Marissa

AU - Grossman, Hillel

AU - Mitsis, Effie

AU - Shah, Raj

AU - Detoledo-Morrell, Leyla

AU - Duara, Ranjan

AU - Varon, Daniel

AU - Greig, Maria

AU - Roberts, Peggy

AU - Albert, Marilyn

AU - Onyike, Chiadi

AU - D'Agostino, Daniel

AU - Kielb, Stephanie

AU - Galvin, James

AU - Cerbone, Brittany

AU - Michel, Christina

AU - Pogorelec, Dana

AU - Rusinek, Henry

AU - De Leon, Mony

AU - Glodzik, Lidia

AU - De Santi, Susan

AU - Doraiswamy, P.

AU - Petrella, Jeffrey

AU - Borges-Neto, Salvador

AU - Wong, Terence

AU - Coleman, Edward

AU - Smith, Charles

AU - Jicha, Greg

AU - Hardy, Peter

AU - Sinha, Partha

AU - Oates, Elizabeth

AU - Conrad, Gary

AU - Porsteinsson, Anton

AU - Goldstein, Bonnie

AU - Martin, Kim

AU - Makino, Kelly

AU - Ismail, M.

AU - Brand, Connie

AU - Mulnard, Ruth

AU - Thai, Gaby

AU - Mc-Adams-Ortiz, Catherine

AU - Womack, Kyle

AU - Mathews, Dana

AU - Quiceno, Mary

AU - Levey, Allan

AU - Lah, James

AU - Cellar, Janet

AU - Burns, Jeffrey

AU - Swerdlow, Russell

AU - Brooks, William

AU - Apostolova, Liana

AU - Tingus, Kathleen

AU - Woo, Ellen

AU - Silverman, Daniel

AU - Lu, Po

AU - Bartzokis, George

AU - Graff-Radford, Neill

AU - Parfitt, Francine

AU - Kendall, Tracy

AU - Johnson, Heather

AU - Farlow, Martin

AU - Marie Hake, Ann

AU - Matthews, Brandy

AU - Brosch, Jared

AU - Herring, Scott

AU - Hunt, Cynthia

AU - Dyck, Christopher

AU - Carson, Richard

AU - MacAvoy, Martha

AU - Varma, Pradeep

AU - Chertkow, Howard

AU - Bergman, Howard

AU - Hosein, Chris

AU - Black, Sandra

AU - Stefanovic, Bojana

AU - Caldwell, Curtis

AU - Robin Hsiung, Ging Yuek

AU - Feldman, Howard

AU - Mudge, Benita

AU - Assaly, Michele

AU - Finger, Elizabeth

AU - Pasternack, Stephen

AU - Rachisky, Irina

AU - Trost, Dick

AU - Kertesz, Andrew

AU - Bernick, Charles

AU - Munic, Donna

AU - Mesulam, Marek Marsel

AU - Lipowski, Kristine

AU - Weintraub, Sandra

AU - Bonakdarpour, Borna

AU - Kerwin, Diana

AU - Wu, Chuang Kuo

AU - Johnson, Nancy

AU - Sadowsky, Carl

AU - Villena, Teresa

AU - Scott Turner, Raymond

AU - Johnson, Kathleen

AU - Reynolds, Brigid

AU - Sperling, Reisa

AU - Johnson, Keith

AU - Marshall, Gad

AU - Yesavage, Jerome

AU - Taylor, Joy

AU - Lane, Barton

AU - Rosen, Allyson

AU - Tinklenberg, Jared

AU - Sabbagh, Marwan

AU - Belden, Christine

AU - Jacobson, Sandra

AU - Sirrel, Sherye

AU - Kowall, Neil

AU - Killiany, Ronald

AU - Budson, Andrew

AU - Norbash, Alexander

AU - Lynn Johnson, Patricia

AU - Obisesan, Thomas

AU - Wolday, Saba

AU - Allard, Joanne

AU - Lerner, Alan

AU - Ogrocki, Paula

AU - Tatsuoka, Curtis

AU - Fatica, Parianne

AU - Fletcher, Evan

AU - Maillard, Pauline

AU - Olichney, John

AU - Decarli, Charles

AU - Carmichael, Owen

AU - Kittur, Smita

AU - Borrie, Michael

AU - Lee, T. Y.

AU - Robbartha,

AU - Johnson, Sterling

AU - Asthana, Sanjay

AU - Carlsson, Cynthia

AU - Potkin, Steven

AU - Preda, Adrian

AU - Nguyen, Dana

AU - Tariot, Pierre

AU - Burke, Anna

AU - Trncic, Nadira

AU - Reeder, Stephanie

AU - Bates, Vernice

AU - Capote, Horacio

AU - Rainka, Michelle

AU - Scharre, Douglas

AU - Kataki, Maria

AU - Adeli, Anahita

AU - Zimmerman, Earl

AU - Celmins, Dzintra

AU - Brown, Alice

AU - Pearlson, Godfrey

AU - Blank, Karen

AU - Anderson, Karen

AU - Flashman, Laura

AU - Seltzer, Marc

AU - Hynes, Mary

AU - Santulli, Robert

AU - Sink, Kaycee

AU - Gordineer, Leslie

AU - Williamson, Jeff

AU - Garg, Pradeep

AU - Watkins, Franklin

AU - Ott, Brian

AU - Querfurth, Henry

AU - Tremont, Geoffrey

AU - Salloway, Stephen

AU - Malloy, Paul

AU - Correia, Stephen

AU - Rosen, Howard

AU - Miller, Bruce

AU - Perry, David

AU - Mintzer, Jacobo

AU - Spicer, Kenneth

AU - Bachman, David

AU - Pomara, Nunzio

AU - Hernando, Raymundo

AU - Sarrael, Antero

AU - Relkin, Norman

AU - Chaing, Gloria

AU - Lin, Michael

AU - Ravdin, Lisa

AU - Smith, Amanda

AU - Ashok Raj, Balebail

AU - Fargher, Kristin

PY - 2017/12/1

Y1 - 2017/12/1

N2 - The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, previous studies have attempted to develop fused predictors of AD and MCI. These studies have two main limitations. Most do not simultaneously consider all diagnostic categories and provide suboptimal fused representations using the same set of modalities for prediction of all classes. In this work, we present a combined framework, cascaded multiview canonical correlation (CaMCCo), for fusion and cascaded classification that incorporates all diagnostic categories and optimizes classification by selectively combining a subset of modalities at each level of the cascade. CaMCCo is evaluated on a data cohort comprising 149 patients for whom neurophysiological, neuroimaging, proteomic and genomic data were available. Results suggest that fusion of select modalities for each classification task outperforms (mean AUC = 0.92) fusion of all modalities (mean AUC = 0.54) and individual modalities (mean AUC = 0.90, 0.53, 0.71, 0.73, 0.62, 0.68). In addition, CaMCCo outperforms all other multi-class classification methods for MCI prediction (PPV: 0.80 vs. 0.67, 0.63).

AB - The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, previous studies have attempted to develop fused predictors of AD and MCI. These studies have two main limitations. Most do not simultaneously consider all diagnostic categories and provide suboptimal fused representations using the same set of modalities for prediction of all classes. In this work, we present a combined framework, cascaded multiview canonical correlation (CaMCCo), for fusion and cascaded classification that incorporates all diagnostic categories and optimizes classification by selectively combining a subset of modalities at each level of the cascade. CaMCCo is evaluated on a data cohort comprising 149 patients for whom neurophysiological, neuroimaging, proteomic and genomic data were available. Results suggest that fusion of select modalities for each classification task outperforms (mean AUC = 0.92) fusion of all modalities (mean AUC = 0.54) and individual modalities (mean AUC = 0.90, 0.53, 0.71, 0.73, 0.62, 0.68). In addition, CaMCCo outperforms all other multi-class classification methods for MCI prediction (PPV: 0.80 vs. 0.67, 0.63).

UR - http://www.scopus.com/inward/record.url?scp=85027495943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027495943&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-03925-0

DO - 10.1038/s41598-017-03925-0

M3 - Article

C2 - 28811553

AN - SCOPUS:85027495943

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 8137

ER -