Case Report and Dosimetric Analysis of an Axillary Recurrence After Partial Breast Irradiation with Mammosite Catheter

Anand P. Shah; Adam Dickler; Michael C. Kirk; Sea S. Chen; Jonathan B. Strauss; Alan B. Coon; Julius V. Turian; Kalliopi Siziopikou; Kambiz Dowlat; Katherine L. Griem

doi:10.1016/j.meddos.2007.11.002

Case Report and Dosimetric Analysis of an Axillary Recurrence After Partial Breast Irradiation with Mammosite Catheter

Anand P. Shah^*, Adam Dickler, Michael C. Kirk, Sea S. Chen, Jonathan B. Strauss, Alan B. Coon, Julius V. Turian, Kalliopi Siziopikou, Kambiz Dowlat, Katherine L. Griem

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Partial breast irradiation (PBI) was designed in part to decrease overall treatment times associated with whole breast radiation therapy (WBRT). WBRT treats the entire breast and usually portions of the axilla. The goal of PBI is to treat a smaller volume of breast tissue in less time, focusing the dose around the lumpectomy cavity. The following is a case of a 64-year-old woman with early-stage breast cancer treated with PBI who failed regionally in the ipsilateral axilla. With our dosimetric analysis, we found that the entire area of this axillary failure would have likely received at least 45 Gy if WBRT had been used, enough to sterilize microscopic disease. With PBI, this area received a mean dose of only 2.8 Gy, which raises the possibility that this regional failure may have been prevented had WBRT been used instead of PBI.

Original language	English (US)
Pages (from-to)	222-225
Number of pages	4
Journal	Medical Dosimetry
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.meddos.2007.11.002
State	Published - Sep 1 2008

Keywords

Axilla
Brachytherapy
Mammosite
Partial breast irradiation

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.meddos.2007.11.002

Cite this

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title = "Case Report and Dosimetric Analysis of an Axillary Recurrence After Partial Breast Irradiation with Mammosite Catheter",

abstract = "Partial breast irradiation (PBI) was designed in part to decrease overall treatment times associated with whole breast radiation therapy (WBRT). WBRT treats the entire breast and usually portions of the axilla. The goal of PBI is to treat a smaller volume of breast tissue in less time, focusing the dose around the lumpectomy cavity. The following is a case of a 64-year-old woman with early-stage breast cancer treated with PBI who failed regionally in the ipsilateral axilla. With our dosimetric analysis, we found that the entire area of this axillary failure would have likely received at least 45 Gy if WBRT had been used, enough to sterilize microscopic disease. With PBI, this area received a mean dose of only 2.8 Gy, which raises the possibility that this regional failure may have been prevented had WBRT been used instead of PBI.",

keywords = "Axilla, Brachytherapy, Mammosite, Partial breast irradiation",

author = "Shah, {Anand P.} and Adam Dickler and Kirk, {Michael C.} and Chen, {Sea S.} and Strauss, {Jonathan B.} and Coon, {Alan B.} and Turian, {Julius V.} and Kalliopi Siziopikou and Kambiz Dowlat and Griem, {Katherine L.}",

year = "2008",

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doi = "10.1016/j.meddos.2007.11.002",

language = "English (US)",

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journal = "Medical Dosimetry",

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T1 - Case Report and Dosimetric Analysis of an Axillary Recurrence After Partial Breast Irradiation with Mammosite Catheter

AU - Shah, Anand P.

AU - Dickler, Adam

AU - Kirk, Michael C.

AU - Chen, Sea S.

AU - Strauss, Jonathan B.

AU - Coon, Alan B.

AU - Turian, Julius V.

AU - Siziopikou, Kalliopi

AU - Dowlat, Kambiz

AU - Griem, Katherine L.

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Partial breast irradiation (PBI) was designed in part to decrease overall treatment times associated with whole breast radiation therapy (WBRT). WBRT treats the entire breast and usually portions of the axilla. The goal of PBI is to treat a smaller volume of breast tissue in less time, focusing the dose around the lumpectomy cavity. The following is a case of a 64-year-old woman with early-stage breast cancer treated with PBI who failed regionally in the ipsilateral axilla. With our dosimetric analysis, we found that the entire area of this axillary failure would have likely received at least 45 Gy if WBRT had been used, enough to sterilize microscopic disease. With PBI, this area received a mean dose of only 2.8 Gy, which raises the possibility that this regional failure may have been prevented had WBRT been used instead of PBI.

AB - Partial breast irradiation (PBI) was designed in part to decrease overall treatment times associated with whole breast radiation therapy (WBRT). WBRT treats the entire breast and usually portions of the axilla. The goal of PBI is to treat a smaller volume of breast tissue in less time, focusing the dose around the lumpectomy cavity. The following is a case of a 64-year-old woman with early-stage breast cancer treated with PBI who failed regionally in the ipsilateral axilla. With our dosimetric analysis, we found that the entire area of this axillary failure would have likely received at least 45 Gy if WBRT had been used, enough to sterilize microscopic disease. With PBI, this area received a mean dose of only 2.8 Gy, which raises the possibility that this regional failure may have been prevented had WBRT been used instead of PBI.

KW - Axilla

KW - Brachytherapy

KW - Mammosite

KW - Partial breast irradiation

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Case Report and Dosimetric Analysis of an Axillary Recurrence After Partial Breast Irradiation with Mammosite Catheter

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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