Case Report and Dosimetric Analysis of an Axillary Recurrence After Partial Breast Irradiation with Mammosite Catheter

Anand P. Shah*, Adam Dickler, Michael C. Kirk, Sea S. Chen, Jonathan B. Strauss, Alan B. Coon, Julius V. Turian, Kalliopi Siziopikou, Kambiz Dowlat, Katherine L. Griem

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Partial breast irradiation (PBI) was designed in part to decrease overall treatment times associated with whole breast radiation therapy (WBRT). WBRT treats the entire breast and usually portions of the axilla. The goal of PBI is to treat a smaller volume of breast tissue in less time, focusing the dose around the lumpectomy cavity. The following is a case of a 64-year-old woman with early-stage breast cancer treated with PBI who failed regionally in the ipsilateral axilla. With our dosimetric analysis, we found that the entire area of this axillary failure would have likely received at least 45 Gy if WBRT had been used, enough to sterilize microscopic disease. With PBI, this area received a mean dose of only 2.8 Gy, which raises the possibility that this regional failure may have been prevented had WBRT been used instead of PBI.

Original languageEnglish (US)
Pages (from-to)222-225
Number of pages4
JournalMedical Dosimetry
Volume33
Issue number3
DOIs
StatePublished - Sep 1 2008

Keywords

  • Axilla
  • Brachytherapy
  • Mammosite
  • Partial breast irradiation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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