Caspase-3 Cleavage of GGA3 Stabilizes BACE: Implications for Alzheimer's Disease

Robert Vassar*

*Corresponding author for this work

Research output: Contribution to journalShort survey

20 Scopus citations

Abstract

BACE initiates the production of β-amyloid (Aβ), the likely cause of Alzheimer's disease (AD). In this issue of Neuron, Tesco et al. show that during apoptosis caspase-3 cleaves the adaptor protein GGA3, which is required for BACE lysosomal degradation, consequently stabilizing BACE and elevating Aβ generation.

Original languageEnglish (US)
Pages (from-to)671-673
Number of pages3
JournalNeuron
Volume54
Issue number5
DOIs
StatePublished - Jun 7 2007

ASJC Scopus subject areas

  • Neuroscience(all)

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