Abstract
BACE initiates the production of β-amyloid (Aβ), the likely cause of Alzheimer's disease (AD). In this issue of Neuron, Tesco et al. show that during apoptosis caspase-3 cleaves the adaptor protein GGA3, which is required for BACE lysosomal degradation, consequently stabilizing BACE and elevating Aβ generation.
Original language | English (US) |
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Pages (from-to) | 671-673 |
Number of pages | 3 |
Journal | Neuron |
Volume | 54 |
Issue number | 5 |
DOIs | |
State | Published - Jun 7 2007 |
ASJC Scopus subject areas
- General Neuroscience