Abstract
Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling.
Original language | English (US) |
---|---|
Pages (from-to) | 4273-4278 |
Number of pages | 6 |
Journal | Cancer Research |
Volume | 66 |
Issue number | 8 |
DOIs | |
State | Published - Apr 15 2006 |
ASJC Scopus subject areas
- Oncology
- Cancer Research