Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions

Brooke Helfer, Bernard C. Boswell, Darren Finlay, Angel Cipres, Kristiina Vuori, Bong Kang Tae, David Wallach, Andrea Dorfleutner, Jill M. Lahti, Daniel C. Flynn, Steven M. Frisch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling.

Original languageEnglish (US)
Pages (from-to)4273-4278
Number of pages6
JournalCancer Research
Volume66
Issue number8
DOIs
StatePublished - Apr 15 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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