Caspase and apoptosis

Xin Tong*, Zhixian Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.

Original languageEnglish (US)
Number of pages1
JournalProgress in Biochemistry and Biophysics
Volume25
Issue number5
StatePublished - Dec 1 1998

Keywords

  • Apoptosis
  • Caspase
  • ICE/CED-3 protease

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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