Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.
|Original language||English (US)|
|Number of pages||1|
|Journal||Progress in Biochemistry and Biophysics|
|State||Published - Dec 1 1998|
- ICE/CED-3 protease
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