Abstract
Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.
Original language | English (US) |
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Number of pages | 1 |
Journal | Progress in Biochemistry and Biophysics |
Volume | 25 |
Issue number | 5 |
State | Published - Dec 1 1998 |
Keywords
- Apoptosis
- Caspase
- ICE/CED-3 protease
ASJC Scopus subject areas
- Biophysics
- Biochemistry