Caspase and apoptosis

Xin Tong; Zhixian Sun

Caspase and apoptosis

Xin Tong^*, Zhixian Sun

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.

Original language	English (US)
Number of pages	1
Journal	Progress in Biochemistry and Biophysics
Volume	25
Issue number	5
State	Published - Dec 1 1998

Keywords

Apoptosis
Caspase
ICE/CED-3 protease

ASJC Scopus subject areas

Biophysics
Biochemistry

Cite this

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title = "Caspase and apoptosis",

abstract = "Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.",

keywords = "Apoptosis, Caspase, ICE/CED-3 protease",

author = "Xin Tong and Zhixian Sun",

year = "1998",

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day = "1",

language = "English (US)",

volume = "25",

journal = "Progress in Biochemistry and Biophysics",

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TY - JOUR

T1 - Caspase and apoptosis

AU - Tong, Xin

AU - Sun, Zhixian

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.

AB - Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.

KW - Apoptosis

KW - Caspase

KW - ICE/CED-3 protease

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M3 - Article

AN - SCOPUS:22444447186

SN - 1000-3282

VL - 25

JO - Progress in Biochemistry and Biophysics

JF - Progress in Biochemistry and Biophysics

IS - 5

ER -

Caspase and apoptosis

Abstract

Keywords

ASJC Scopus subject areas

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