Caspase and apoptosis

Xin Tong; Zhixian Sun

Caspase and apoptosis

Xin Tong^*, Zhixian Sun

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.

Original language	English (US)
Number of pages	1
Journal	Progress in Biochemistry and Biophysics
Volume	25
Issue number	5
State	Published - Dec 1 1998

Keywords

Apoptosis
Caspase
ICE/CED-3 protease

ASJC Scopus subject areas

Biophysics
Biochemistry

Fingerprint Dive into the research topics of 'Caspase and apoptosis'. Together they form a unique fingerprint.

Cite this

@article{1564cbc338024c75b26a2519394cad26,

title = "Caspase and apoptosis",

abstract = "Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.",

keywords = "Apoptosis, Caspase, ICE/CED-3 protease",

author = "Xin Tong and Zhixian Sun",

year = "1998",

month = dec,

day = "1",

language = "English (US)",

volume = "25",

journal = "Progress in Biochemistry and Biophysics",

issn = "1000-3282",

publisher = "Science Press",

number = "5",

}

TY - JOUR

T1 - Caspase and apoptosis

AU - Tong, Xin

AU - Sun, Zhixian

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.

AB - Since the discovery of structural and functional similarities between the product of the nematode cell-death gene Ced-3 and mammalian interleukin-1β-converting enzyme (ICE), an expanding family of cysteine proteases genes have been coloned and shown to play a key role in execution stage of mammalian cell apoptosis. Several substrates are found to be cleaved by the active ICE/CED-3 proteases (because of cysteine protease with aspartates specificity, also called caspase), and subsequent cytological effect is induced.

KW - Apoptosis

KW - Caspase

KW - ICE/CED-3 protease

UR - http://www.scopus.com/inward/record.url?scp=22444447186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22444447186&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:22444447186

VL - 25

JO - Progress in Biochemistry and Biophysics

JF - Progress in Biochemistry and Biophysics

SN - 1000-3282

IS - 5

ER -

Caspase and apoptosis

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Cite this