Catalase and PPARγ2 genotype and risk of rheumatoid arthritis in Koreans

Ahmed El-Sohemy; Marilyn C. Cornelis; Yong Wook Park; Sang Cheol Bae

doi:10.1007/s00296-005-0013-3

Catalase and PPARγ2 genotype and risk of rheumatoid arthritis in Koreans

Ahmed El-Sohemy, Marilyn C. Cornelis, Yong Wook Park, Sang Cheol Bae^*

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Catalase (CAT) and peroxisome proliferator activated receptor-γ2 (PPARγ2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARγ2 genotypes and risk and severity of RA using 474 cases and 400 controls. Genotyping for the -262C → T polymorphism of CAT and the Pro12Ala polymorphism of PPARγ2 was performed by PCR-RFLP analysis. Severity of RA was assessed by the anatomical stage according to Steinbrocker, and a Korean language version of a Health Assessment Questionnaire (KHAQ). No association was observed between CAT and PPARγ2 genotypes and risk of RA. Our results suggest that genetic polymorphisms of CAT and PPARγ2 do not play a significant role in the susceptibility to RA among Koreans.

Original language	English (US)
Pages (from-to)	388-392
Number of pages	5
Journal	Rheumatology International
Volume	26
Issue number	5
DOIs	https://doi.org/10.1007/s00296-005-0013-3
State	Published - Mar 2006

Keywords

Catalase
Genotype
Korean
PPARγ
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

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abstract = "Catalase (CAT) and peroxisome proliferator activated receptor-γ2 (PPARγ2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARγ2 genotypes and risk and severity of RA using 474 cases and 400 controls. Genotyping for the -262C → T polymorphism of CAT and the Pro12Ala polymorphism of PPARγ2 was performed by PCR-RFLP analysis. Severity of RA was assessed by the anatomical stage according to Steinbrocker, and a Korean language version of a Health Assessment Questionnaire (KHAQ). No association was observed between CAT and PPARγ2 genotypes and risk of RA. Our results suggest that genetic polymorphisms of CAT and PPARγ2 do not play a significant role in the susceptibility to RA among Koreans.",

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AU - Cornelis, Marilyn C.

AU - Park, Yong Wook

AU - Bae, Sang Cheol

PY - 2006/3

Y1 - 2006/3

N2 - Catalase (CAT) and peroxisome proliferator activated receptor-γ2 (PPARγ2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARγ2 genotypes and risk and severity of RA using 474 cases and 400 controls. Genotyping for the -262C → T polymorphism of CAT and the Pro12Ala polymorphism of PPARγ2 was performed by PCR-RFLP analysis. Severity of RA was assessed by the anatomical stage according to Steinbrocker, and a Korean language version of a Health Assessment Questionnaire (KHAQ). No association was observed between CAT and PPARγ2 genotypes and risk of RA. Our results suggest that genetic polymorphisms of CAT and PPARγ2 do not play a significant role in the susceptibility to RA among Koreans.

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