Abstract
Catalase (CAT) and peroxisome proliferator activated receptor-γ2 (PPARγ2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARγ2 genotypes and risk and severity of RA using 474 cases and 400 controls. Genotyping for the -262C → T polymorphism of CAT and the Pro12Ala polymorphism of PPARγ2 was performed by PCR-RFLP analysis. Severity of RA was assessed by the anatomical stage according to Steinbrocker, and a Korean language version of a Health Assessment Questionnaire (KHAQ). No association was observed between CAT and PPARγ2 genotypes and risk of RA. Our results suggest that genetic polymorphisms of CAT and PPARγ2 do not play a significant role in the susceptibility to RA among Koreans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 388-392 |
| Number of pages | 5 |
| Journal | Rheumatology International |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 2006 |
Funding
Acknowledgements This work was supported in part by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ3-PG6-01GN11-0002). We gratefully acknowledge Eun-Joo Kwak and Eun-Kyoung Ju for data collection and management and Jung-Ah Kim for DNA preparation.
Keywords
- Catalase
- Genotype
- Korean
- PPARγ
- Rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology