Catalase and PPARγ2 genotype and risk of rheumatoid arthritis in Koreans

Ahmed El-Sohemy, Marilyn C. Cornelis, Yong Wook Park, Sang Cheol Bae*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Catalase (CAT) and peroxisome proliferator activated receptor-γ2 (PPARγ2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARγ2 genotypes and risk and severity of RA using 474 cases and 400 controls. Genotyping for the -262C → T polymorphism of CAT and the Pro12Ala polymorphism of PPARγ2 was performed by PCR-RFLP analysis. Severity of RA was assessed by the anatomical stage according to Steinbrocker, and a Korean language version of a Health Assessment Questionnaire (KHAQ). No association was observed between CAT and PPARγ2 genotypes and risk of RA. Our results suggest that genetic polymorphisms of CAT and PPARγ2 do not play a significant role in the susceptibility to RA among Koreans.

Original languageEnglish (US)
Pages (from-to)388-392
Number of pages5
JournalRheumatology International
Volume26
Issue number5
DOIs
StatePublished - Mar 2006

Keywords

  • Catalase
  • Genotype
  • Korean
  • PPARγ
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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