(Chemical Equation Presented) The addition of acylsilanes to imines catalyzed by neutral carbenes (or zwitterions) generated in situ from readily available thiazolium salts is described. The general reaction successfully utilizes acylsilanes as carbonyl anion precursors and is tolerant of a range of structural diversity on the acylsilane or imine electrophile. The overall reaction utilizes easily available precursors and directly accesses protected α-amino ketones in the correct oxidation state.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Nov 11 2004|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry