Abstract
The global catalyst industry is valued at nearly 20 billion USD and demand continues to rise. Enzymes, biological macromolecules, are highly selective and efficient catalysts; however, their commercial implementation has been hindered due to their poor chemical and thermal stability and low reusability. Numerous strategies have been investigated to stabilize enzymes and improve their processability. Recently, metal–organic frameworks (MOFs) have been investigated as enzyme immobilization supports. Herein, we highlight the immobilization of enzymes in MOF cages and pores for catalysis applications and discuss the future of this enzyme encapsulation strategy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 151-160 |
| Number of pages | 10 |
| Journal | Coordination Chemistry Reviews |
| Volume | 381 |
| DOIs | |
| State | Published - Feb 15 2019 |
Funding
The authors are grateful for financial support from the Defense Threat Reduction Agency ( HDTRA1-18-1-0003 ), the U.S. Department of Energy, Nuclear Security Administration under Award Number DE-NA0003763 , and Northwestern University . R.J.D. appreciates support from the Ryan Fellowship and the International Institute for Nanotechnology .
Keywords
- Biocatalysis
- Enzyme immobilization
- Metal–organic frameworks
ASJC Scopus subject areas
- Materials Chemistry
- General Chemistry
- Inorganic Chemistry
- Physical and Theoretical Chemistry