Catalytic enantioselective synthesis of 2-aryl-chromenes

Bi Shun Zeng, Xinyi Yu, Paul W. Siu, Karl A. Scheidt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


An enantioselective Pd-catalyzed 6-endo-trig reaction for the synthesis of 2-aryl-chromenes has been developed. A systematic optimization of a TADDOL-derived ligand set resulted in the identification of a novel monodentate phosphoramidite-palladium catalyst that accesses 2-aryl-2H-chromenes with high yield and enantioselectivity under mild conditions. The products obtained from this method can be transformed into biologically active compounds through functionalization of the chromene alkene. This journal is

Original languageEnglish (US)
Pages (from-to)2277-2281
Number of pages5
JournalChemical Science
Issue number6
StatePublished - Jun 2014

ASJC Scopus subject areas

  • General Chemistry


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