Catastrophic multiple organ ischemia due to an anti-Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximab

Joshua Ruch, Brandon McMahon, Glenn Ramsey, Hau C. Kwaan

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Cold agglutinin disease occurring with cryoglobulinemia is a rare occurrence. Here, we report a patient with mixed cryoglobulinemia that was treated with rituximab and, after response, developed an anti-Pr cold agglutinin that manifested with hemolysis and microvascular occlusion causing mesenteric ischemia and cerebral infarction. Unlike previous reports of patients with cryoglobulinemia and cold agglutinin disease, our patient did not have a detectable cryoprecipitate when his cold agglutinin manifested.

Original languageEnglish (US)
Pages (from-to)120-122
Number of pages3
JournalAmerican Journal of Hematology
Volume84
Issue number2
DOIs
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Hematology

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