Cathepsin B: A sellsword of cancer progression

Olja Mijanović, Ana Branković, Alexander N. Panin, Solomiia Savchuk, Peter Timashev, Ilya Ulasov, Maciej S Lesniak

Research output: Contribution to journalShort survey

Abstract

Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next – from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalCancer Letters
Volume449
DOIs
StatePublished - May 1 2019

Fingerprint

Cathepsin B
Cathepsins
Peptide Hydrolases
Neoplasms
Neoplasm Metastasis
Extracellular Matrix Proteins
Caspases
Lysosomes
Neurodegenerative Diseases
Molecular Biology
Homeostasis
Maintenance
Apoptosis
Inflammation
Therapeutics
Growth
Infection

Keywords

  • Autophagy
  • Cathepsin B
  • Migration
  • Tumor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, I., & Lesniak, M. S. (2019). Cathepsin B: A sellsword of cancer progression. Cancer Letters, 449, 207-214. https://doi.org/10.1016/j.canlet.2019.02.035
Mijanović, Olja ; Branković, Ana ; Panin, Alexander N. ; Savchuk, Solomiia ; Timashev, Peter ; Ulasov, Ilya ; Lesniak, Maciej S. / Cathepsin B : A sellsword of cancer progression. In: Cancer Letters. 2019 ; Vol. 449. pp. 207-214.
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Mijanović, O, Branković, A, Panin, AN, Savchuk, S, Timashev, P, Ulasov, I & Lesniak, MS 2019, 'Cathepsin B: A sellsword of cancer progression' Cancer Letters, vol. 449, pp. 207-214. https://doi.org/10.1016/j.canlet.2019.02.035

Cathepsin B : A sellsword of cancer progression. / Mijanović, Olja; Branković, Ana; Panin, Alexander N.; Savchuk, Solomiia; Timashev, Peter; Ulasov, Ilya; Lesniak, Maciej S.

In: Cancer Letters, Vol. 449, 01.05.2019, p. 207-214.

Research output: Contribution to journalShort survey

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Mijanović O, Branković A, Panin AN, Savchuk S, Timashev P, Ulasov I et al. Cathepsin B: A sellsword of cancer progression. Cancer Letters. 2019 May 1;449:207-214. https://doi.org/10.1016/j.canlet.2019.02.035