Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery

Mengdi Han, Lin Chen, Kedar Aras, Cunman Liang, Xuexian Chen, Hangbo Zhao, Kan Li, Ndeye Rokhaya Faye, Bohan Sun, Jae Hwan Kim, Wubin Bai, Quansan Yang, Yuhang Ma, Wei Lu, Enming Song, Janice Mihyun Baek, Yujin Lee, Clifford Liu, Jeffrey B. Model, Guanjun YangRoozbeh Ghaffari, Yonggang Huang*, Igor R. Efimov, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes.

Original languageEnglish (US)
Pages (from-to)997-1009
Number of pages13
JournalNature Biomedical Engineering
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2020

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

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