Catheterization diastolic pressures correlate with diastolic dyssynchrony in patients with single right ventricles

Corey Stiver, Janaki Gokhale, Nazia Husain, Lisa Nicholson, Joyce Cordier, Lindsey Van Lente, Ralf J. Holzer, Clifford L. Cua*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Diastolic dyssynchrony has correlated with pulmonary capillary wedge pressures in patients with normal cardiac anatomy. No data exist in single right ventricle (sRV) patients. Goal of this study was to determine if diastolic dyssynchrony in sRV patients correlates with ventricular end-diastolic pressures (VEDP). Methods: Tissue Doppler imaging (TDI) and strain rate (SR) analysis of sRV patients undergoing catheterization were performed. Time interval from onset of QRS to peak TDI e'-wave was obtained. Differences in intervals were calculated: QRS (RV) - QRS (IVS) and QRS (RV) - QRS (LV). Time interval from onset of QRS to peak strain rate early diastolic wave (SRe) was obtained for the 6 segment model sRV. Standard deviation of the 6 SRe time intervals was calculated. Correlation of VEDP with timing intervals was analyzed. Results: Forty sRV patients were evaluated. Age was 2.8 ± 3.5 years. Catheterization VEDP of the sRV was 9.3 ± 3.9 mmHg (median 8 mmHg range 4-24 mmHg). QRS (RV) - QRS (IVS) was 22.3 ± 18.1 msec and QRS (RV) - QRS (LV) was 23.7 ± 19.0 msec. SRe standard deviation of the sRV was 61.6 ± 23.9 msec. There was no significant correlation with VEDP and QRS (RV) - QRS (IVS) (r = 0.1, P = NS) or with QRS (RV) - QRS (LV) (r = 0.2, P = NS). There was a significant correlation of VEDP with the SRe standard deviation value (r = 0.4, P < 0.05). Conclusion: Diastolic dyssynchrony correlated with VEDP in patients with sRV physiology. Future studies are needed to determine the significance of these findings.

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalEchocardiography
Volume31
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • catheterization
  • congenital heart disease
  • diastole
  • dyssynchrony
  • echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Stiver, C., Gokhale, J., Husain, N., Nicholson, L., Cordier, J., Van Lente, L., Holzer, R. J., & Cua, C. L. (2014). Catheterization diastolic pressures correlate with diastolic dyssynchrony in patients with single right ventricles. Echocardiography, 31(3), 370-374. https://doi.org/10.1111/echo.12373