Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Trace eyeblink conditioning (EBC) is an associative learning task in which a stimulus-free trace period separates the presentation of a behaviorally neutral conditioned stimulus (CS; whisker stimulation) from a behaviorally salient unconditioned stimulus (US; air puff to the eye). Repeated pairings of the CS with the US results in the emergence of the conditioned response (CR; eyeblink after CS presentation and before US presentation). The goal of these experiments was to determine whether the caudate nucleus (CN) plays a role in retrieval of previously acquired trace EBC after memory consolidation. Lesions of the CN were made 1 month after initial trace EBC. CN-lesioned rabbits performed fewer adaptive CRs and more short-latency non-adaptive responses than sham-lesioned controls. They were not able to improve their CR performance after consolidation as were controls. Single-unit recordings taken from separate cohorts of rabbits demonstrated that neurons in the CN were still responsive to the CS and US 1 month after initial trace EBC, particularly in the medial and ventral CN on trials when a CR occurred. The proportion of rate-increasing neurons was higher in trace-conditioned than in pseudoconditioned rabbits. Neurons in regions destroyed in the behavioral experiment demonstrated prolonged firing during the trace period, which might underlie the results from the behavioral experiment. These data demonstrate that the CN plays an important role in retrieval of a previously learned associative task after memory consolidation has occurred.

Original languageEnglish (US)
Pages (from-to)2828-2836
Number of pages9
JournalJournal of Neuroscience
Volume33
Issue number7
DOIs
StatePublished - Feb 13 2013

Fingerprint

Caudate Nucleus
Rabbits
Neurons
Vibrissae
Conditioning (Psychology)
Air
Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{a557aa13c8a74bd9acb404fc5728be09,
title = "Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation",
abstract = "Trace eyeblink conditioning (EBC) is an associative learning task in which a stimulus-free trace period separates the presentation of a behaviorally neutral conditioned stimulus (CS; whisker stimulation) from a behaviorally salient unconditioned stimulus (US; air puff to the eye). Repeated pairings of the CS with the US results in the emergence of the conditioned response (CR; eyeblink after CS presentation and before US presentation). The goal of these experiments was to determine whether the caudate nucleus (CN) plays a role in retrieval of previously acquired trace EBC after memory consolidation. Lesions of the CN were made 1 month after initial trace EBC. CN-lesioned rabbits performed fewer adaptive CRs and more short-latency non-adaptive responses than sham-lesioned controls. They were not able to improve their CR performance after consolidation as were controls. Single-unit recordings taken from separate cohorts of rabbits demonstrated that neurons in the CN were still responsive to the CS and US 1 month after initial trace EBC, particularly in the medial and ventral CN on trials when a CR occurred. The proportion of rate-increasing neurons was higher in trace-conditioned than in pseudoconditioned rabbits. Neurons in regions destroyed in the behavioral experiment demonstrated prolonged firing during the trace period, which might underlie the results from the behavioral experiment. These data demonstrate that the CN plays an important role in retrieval of a previously learned associative task after memory consolidation has occurred.",
author = "Flores, {Luke C.} and Disterhoft, {John F}",
year = "2013",
month = "2",
day = "13",
doi = "10.1523/JNEUROSCI.2326-12.2013",
language = "English (US)",
volume = "33",
pages = "2828--2836",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "7",

}

Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation. / Flores, Luke C.; Disterhoft, John F.

In: Journal of Neuroscience, Vol. 33, No. 7, 13.02.2013, p. 2828-2836.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation

AU - Flores, Luke C.

AU - Disterhoft, John F

PY - 2013/2/13

Y1 - 2013/2/13

N2 - Trace eyeblink conditioning (EBC) is an associative learning task in which a stimulus-free trace period separates the presentation of a behaviorally neutral conditioned stimulus (CS; whisker stimulation) from a behaviorally salient unconditioned stimulus (US; air puff to the eye). Repeated pairings of the CS with the US results in the emergence of the conditioned response (CR; eyeblink after CS presentation and before US presentation). The goal of these experiments was to determine whether the caudate nucleus (CN) plays a role in retrieval of previously acquired trace EBC after memory consolidation. Lesions of the CN were made 1 month after initial trace EBC. CN-lesioned rabbits performed fewer adaptive CRs and more short-latency non-adaptive responses than sham-lesioned controls. They were not able to improve their CR performance after consolidation as were controls. Single-unit recordings taken from separate cohorts of rabbits demonstrated that neurons in the CN were still responsive to the CS and US 1 month after initial trace EBC, particularly in the medial and ventral CN on trials when a CR occurred. The proportion of rate-increasing neurons was higher in trace-conditioned than in pseudoconditioned rabbits. Neurons in regions destroyed in the behavioral experiment demonstrated prolonged firing during the trace period, which might underlie the results from the behavioral experiment. These data demonstrate that the CN plays an important role in retrieval of a previously learned associative task after memory consolidation has occurred.

AB - Trace eyeblink conditioning (EBC) is an associative learning task in which a stimulus-free trace period separates the presentation of a behaviorally neutral conditioned stimulus (CS; whisker stimulation) from a behaviorally salient unconditioned stimulus (US; air puff to the eye). Repeated pairings of the CS with the US results in the emergence of the conditioned response (CR; eyeblink after CS presentation and before US presentation). The goal of these experiments was to determine whether the caudate nucleus (CN) plays a role in retrieval of previously acquired trace EBC after memory consolidation. Lesions of the CN were made 1 month after initial trace EBC. CN-lesioned rabbits performed fewer adaptive CRs and more short-latency non-adaptive responses than sham-lesioned controls. They were not able to improve their CR performance after consolidation as were controls. Single-unit recordings taken from separate cohorts of rabbits demonstrated that neurons in the CN were still responsive to the CS and US 1 month after initial trace EBC, particularly in the medial and ventral CN on trials when a CR occurred. The proportion of rate-increasing neurons was higher in trace-conditioned than in pseudoconditioned rabbits. Neurons in regions destroyed in the behavioral experiment demonstrated prolonged firing during the trace period, which might underlie the results from the behavioral experiment. These data demonstrate that the CN plays an important role in retrieval of a previously learned associative task after memory consolidation has occurred.

UR - http://www.scopus.com/inward/record.url?scp=84873691921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873691921&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.2326-12.2013

DO - 10.1523/JNEUROSCI.2326-12.2013

M3 - Article

C2 - 23407942

AN - SCOPUS:84873691921

VL - 33

SP - 2828

EP - 2836

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 7

ER -