Causal inference of interaction effects with inverse propensity weighting, G-computation and tree-based standardization

Joseph Kang*, Xiaogang Su, Lei Liu, Martha L. Daviglus

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Given the recent interest of subgroup-level studies and personalized medicine, health research with causal inference has been developed for interaction effects of measured confounders. In estimating interaction effects, the inverse of the propensity weighting (IPW) method has been widely advocated despite the immediate availability of other competing methods such as G-computation estimates. This paper compares the advocated IPW method, the G-computation method, and our new Tree-based standardization method, which we call the Interaction effect Tree (IT). The IT procedure uses a likelihood-based decision rule to divide the subgroups into homogeneous groups where the G-computation can be applied. Our simulation studies indicate that the IT-based method along with the G-computation works robustly while the advocated IPW method needs some caution in its weighting. We applied the IT-based method to assess the effect of being overweight or obese on coronary artery calcification (CAC) in the Chicago Healthy Aging Study cohort.

Original languageEnglish (US)
Pages (from-to)323-336
Number of pages14
JournalStatistical Analysis and Data Mining
Volume7
Issue number5
DOIs
StatePublished - 2014

Keywords

  • Causal inference
  • G-computation
  • Interaction effects
  • Marginal structural model
  • Tree analysis

ASJC Scopus subject areas

  • Analysis
  • Information Systems
  • Computer Science Applications

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