Causes versus effects: The increasing complexities of Alzheimer's disease pathogenesis

Siddhartha Mondragón-Rodríguez, Gustavo Basurto-Islas, Hyoung Gon Lee, George Perry, Xiongwei Zhu, Rudy J. Castellani, Mark A. Smith

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Amyloid plaques and neurofibrillary tangles are the hallmarks of Alzheimer's disease and have been the focus of disease etiology and pathogenesis. However, in the larger picture of a complex disease, the precise etiology of the lesions per se, as well as the clinical disease, remain to be defined. In this regard, to date no single process has been identified as a useful target and treatment efforts have shown no meaningful progress. Therefore, alternative ideas that may lead to new and effective treatment options are much needed.

Original languageEnglish (US)
Pages (from-to)683-691
Number of pages9
JournalExpert Review of Neurotherapeutics
Issue number5
StatePublished - May 2010
Externally publishedYes


  • Alzheimer's disease
  • Amyloid
  • Fibrillary deposits
  • Oxidative stress
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)


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