Caution against using propylene glycol as a solvent in epilepsy drug research

M. Matthew Oh, John M. Power, Lucien T. Thompson, John F. Disterhoft

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Anticonvulsive effects and changes in chemical species reflecting nitric oxide production (NOx levels) were induced in the EL mouse by a solvent mixture commonly used to dissolve antiepileptic drugs. The mixture consisted of propylene glycol (PG) and ethanol in saline (PES), and included 10.5% ethanol plus 20, 40, or 60% PG. PES mixtures suppressed seizures in EL mice in proportion to concentrations of PG. NOx levels in the brains of mice treated with PES mixtures including 40 or 60% PG were significantly lower than in control mouse brain. These results suggested that anticonvulsive effects of PES mixtures were related to reduction of NOx levels in brain. PG should not be used as a drug solvent in epilepsy research.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalNeuroscience Research Communications
Volume27
Issue number2
DOIs
StatePublished - Nov 20 2000

Keywords

  • Anticonvulsive effect
  • Antiepileptic drug
  • Experimental design
  • Nitric oxide
  • Propylene glycol
  • Solvents

ASJC Scopus subject areas

  • Neuroscience(all)

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