Caution against using propylene glycol as a solvent in epilepsy drug research

M. Matthew Oh; John M. Power; Lucien T. Thompson; John F. Disterhoft

doi:10.1002/1520-6769(200009/10)27:2<117::AID-NRC5>3.0.CO;2-Z

Caution against using propylene glycol as a solvent in epilepsy drug research

M. Matthew Oh, John M. Power, Lucien T. Thompson, John F. Disterhoft

Neuroscience

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Anticonvulsive effects and changes in chemical species reflecting nitric oxide production (NOx levels) were induced in the EL mouse by a solvent mixture commonly used to dissolve antiepileptic drugs. The mixture consisted of propylene glycol (PG) and ethanol in saline (PES), and included 10.5% ethanol plus 20, 40, or 60% PG. PES mixtures suppressed seizures in EL mice in proportion to concentrations of PG. NOx levels in the brains of mice treated with PES mixtures including 40 or 60% PG were significantly lower than in control mouse brain. These results suggested that anticonvulsive effects of PES mixtures were related to reduction of NOx levels in brain. PG should not be used as a drug solvent in epilepsy research.

Original language	English (US)
Pages (from-to)	117-124
Number of pages	8
Journal	Neuroscience Research Communications
Volume	27
Issue number	2
DOIs	https://doi.org/10.1002/1520-6769(200009/10)27:2<117::AID-NRC5>3.0.CO;2-Z
State	Published - 2000

Keywords

Anticonvulsive effect
Antiepileptic drug
Experimental design
Nitric oxide
Propylene glycol
Solvents

ASJC Scopus subject areas

General Neuroscience

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10.1002/1520-6769(200009/10)27:2<117::AID-NRC5>3.0.CO;2-Z

Cite this

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title = "Caution against using propylene glycol as a solvent in epilepsy drug research",

abstract = "Anticonvulsive effects and changes in chemical species reflecting nitric oxide production (NOx levels) were induced in the EL mouse by a solvent mixture commonly used to dissolve antiepileptic drugs. The mixture consisted of propylene glycol (PG) and ethanol in saline (PES), and included 10.5% ethanol plus 20, 40, or 60% PG. PES mixtures suppressed seizures in EL mice in proportion to concentrations of PG. NOx levels in the brains of mice treated with PES mixtures including 40 or 60% PG were significantly lower than in control mouse brain. These results suggested that anticonvulsive effects of PES mixtures were related to reduction of NOx levels in brain. PG should not be used as a drug solvent in epilepsy research.",

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author = "Oh, {M. Matthew} and Power, {John M.} and Thompson, {Lucien T.} and Disterhoft, {John F.}",

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AU - Oh, M. Matthew

AU - Power, John M.

AU - Thompson, Lucien T.

AU - Disterhoft, John F.

PY - 2000

Y1 - 2000

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AB - Anticonvulsive effects and changes in chemical species reflecting nitric oxide production (NOx levels) were induced in the EL mouse by a solvent mixture commonly used to dissolve antiepileptic drugs. The mixture consisted of propylene glycol (PG) and ethanol in saline (PES), and included 10.5% ethanol plus 20, 40, or 60% PG. PES mixtures suppressed seizures in EL mice in proportion to concentrations of PG. NOx levels in the brains of mice treated with PES mixtures including 40 or 60% PG were significantly lower than in control mouse brain. These results suggested that anticonvulsive effects of PES mixtures were related to reduction of NOx levels in brain. PG should not be used as a drug solvent in epilepsy research.

KW - Anticonvulsive effect

KW - Antiepileptic drug

KW - Experimental design

KW - Nitric oxide

KW - Propylene glycol

KW - Solvents

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Caution against using propylene glycol as a solvent in epilepsy drug research

Abstract

Keywords

ASJC Scopus subject areas

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