CD1-Restricted T Cells in Inflammatory Skin Diseases

Samantha Genardi, Eva Morgun, Chyung Ru Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells recognize lipid antigens rather than peptide antigens and have been implicated in various autoimmune skin conditions, including psoriasis and atopic dermatitis. In this review, we will discuss the self-lipids that CD1-restricted T cells recognize and how these T cells become aberrantly regulated in pathogenic skin conditions.

Original languageEnglish (US)
Pages (from-to)768-773
Number of pages6
JournalJournal of Investigative Dermatology
Volume142
Issue number3
DOIs
StatePublished - Mar 2022

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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