CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease

Laurence M. Howard; Katherine L. Neville; Lia M. Haynes; Mauro C. Dal Canto; Stephen D. Miller

doi:10.1128/JVI.77.3.2247-2250.2003

CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease

Laurence M. Howard, Katherine L. Neville, Lia M. Haynes, Mauro C. Dal Canto, Stephen D. Miller^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.

Original language	English (US)
Pages (from-to)	2247-2250
Number of pages	4
Journal	Journal of virology
Volume	77
Issue number	3
DOIs	https://doi.org/10.1128/JVI.77.3.2247-2250.2003
State	Published - Feb 2003

ASJC Scopus subject areas

Insect Science
Virology
Microbiology
Immunology

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10.1128/JVI.77.3.2247-2250.2003

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title = "CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease",

abstract = "Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.",

author = "Howard, {Laurence M.} and Neville, {Katherine L.} and Haynes, {Lia M.} and {Dal Canto}, {Mauro C.} and Miller, {Stephen D.}",

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AU - Howard, Laurence M.

AU - Neville, Katherine L.

AU - Haynes, Lia M.

AU - Dal Canto, Mauro C.

AU - Miller, Stephen D.

PY - 2003/2

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N2 - Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.

AB - Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.

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CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease

Abstract

ASJC Scopus subject areas

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