CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease

Laurence M. Howard, Katherine L. Neville, Lia M. Haynes, Mauro C. Dal Canto, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.

Original languageEnglish (US)
Pages (from-to)2247-2250
Number of pages4
JournalJournal of virology
Volume77
Issue number3
DOIs
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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