CD16+ monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells

Petronela Ancuta, Kevin J. Kunstman, Patrick Autissier, Tauheed Zaman, David Stone, Steven M. Wolinsky, Dana Gabuzda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

The CD16+ subset of monocytes is dramatically expanded in peripheral blood during progression to AIDS, but its contribution to HIV pathogenesis is unknown. Here, we demonstrate that CD16+ but not CD16- monocytes promote high levels of HIV replication upon differentiation into macrophages and interaction with T cells. Conjugates formed between CD16+ monocyte-derived macrophages and T cells are major sites of viral replication. Furthermore, similar monocyte-T cell conjugates detected in peripheral blood of HIV-infected patients harbor HIV DNA. Thus, expansion of CD16+ monocytes during HIV infection and their subsequent recruitment into tissues such as lymph nodes, brain, and intestine may contribute to HIV dissemination and establishment of productive infection in T cells.

Original languageEnglish (US)
Pages (from-to)267-276
Number of pages10
JournalVirology
Volume344
Issue number2
DOIs
StatePublished - Jan 20 2006

Keywords

  • CD16 monocytes
  • Conjugates
  • HIV
  • T cells

ASJC Scopus subject areas

  • Virology

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