CD26/dipeptidyl peptidase IV and its role in cancer

B. Pro, Nam H. Dang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations


CD26/Dipeptidyl Peptidase IV (DPPIV) is a 110-kDa glycoprotein that is expressed on numerous cell types and has multiple biological functions. A key facet of CD26/DPPIV biology is its enzymatic activity and its physical and functional interaction with other molecules. The substrates of CD26/DPPIV are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays an important role in immune regulation, signal transduction, and apoptosis. Furthermore, CD26 appears to play an important role in tumor progression. In the present review, we summarize key aspects of CD26/DPPIV involvement in tumor biology and its potential role in cancer development and behavior.

Original languageEnglish (US)
Pages (from-to)1345-1351
Number of pages7
JournalHistology and histopathology
Issue number4
StatePublished - Oct 1 2004


  • CD26/DPPIV
  • Cancer
  • Chemokines
  • T cell lymphoid malignancies
  • Targeted therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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