CD3 in Lewy pathology: Does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease

Rudy J. Castellani, Summer L. Nugent, Alan L. Morrison, Xiongwei Zhu, Hyoung Gon Lee, Peggy L.R. Harris, Vladan Bajić, Hari S. Sharma, Shu G. Chen, Peter Oettgen, George Perry, Mark A. Smith

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

CD3ζ is a subunit of the CD3 molecule that, until recently, appeared restricted to T cells and natural killer cells. However, experimental studies have demonstrated a role of CD3ζ in dendritic outgrowth in the visual system as well as in synaptic plasticity. Given the increasing evidence for uncharacteristic recapitulation of neurodevelopmental processes in neurodegenerative diseases, in this study, we evaluated brains from subjects with Parkinson's disease and Lewy body dementia for evidence of aberrant CD3 expression. Our data shows marked CD3ζ in association with the α-synuclein containing pathological lesions, i.e., Lewy bodies and Lewy neurites, in the brains of subjects with Parkinson's disease and Lewy body dementia. This finding raises the novel concept of CD3 dysregulation in these disorders as a pathogenic factor and also furthers the increasing evidence that the recall of aberrant neurodevelopmental processes underlies the pathogenesis of neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalJournal of Neural Transmission
Volume118
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Alpha-synuclein
  • CD3
  • Lewy bodies
  • Lewy body dementia
  • Lewy neurites
  • Neurodevelopment
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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