CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)

Narayanaswamy Ramesh*, Tomohiro Morio, Ramsay Fuleihan, Margitta Worm, Anthony Horner, Erdyni Tsitsikov, Emanuela Castigli, Raif S. Geha

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.

Original languageEnglish (US)
Pages (from-to)S208-S213
JournalClinical Immunology and Immunopathology
Issue number3 PART 2
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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