Abstract
Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.
Original language | English (US) |
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Pages (from-to) | S208-S213 |
Journal | Clinical Immunology and Immunopathology |
Volume | 76 |
Issue number | 3 PART 2 |
DOIs | |
State | Published - Sep 1995 |
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology