CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)

Narayanaswamy Ramesh*, Tomohiro Morio, Ramsay Fuleihan, Margitta Worm, Anthony Horner, Erdyni Tsitsikov, Emanuela Castigli, Raif S. Geha

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.

Original languageEnglish (US)
JournalClinical Immunology and Immunopathology
Volume76
Issue number3 PART 2
DOIs
StatePublished - Jan 1 1995

Fingerprint

Immunoglobulin Class Switching
CD40 Ligand
T-Lymphocytes
Surface Antigens
B-Lymphocytes
Antigens
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Cite this

Ramesh, Narayanaswamy ; Morio, Tomohiro ; Fuleihan, Ramsay ; Worm, Margitta ; Horner, Anthony ; Tsitsikov, Erdyni ; Castigli, Emanuela ; Geha, Raif S. / CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). In: Clinical Immunology and Immunopathology. 1995 ; Vol. 76, No. 3 PART 2.
@article{7d1d7357f5c14a778412f34efe2c2643,
title = "CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)",
abstract = "Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.",
author = "Narayanaswamy Ramesh and Tomohiro Morio and Ramsay Fuleihan and Margitta Worm and Anthony Horner and Erdyni Tsitsikov and Emanuela Castigli and Geha, {Raif S.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1016/S0090-1229(95)90252-X",
language = "English (US)",
volume = "76",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "3 PART 2",

}

CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). / Ramesh, Narayanaswamy; Morio, Tomohiro; Fuleihan, Ramsay; Worm, Margitta; Horner, Anthony; Tsitsikov, Erdyni; Castigli, Emanuela; Geha, Raif S.

In: Clinical Immunology and Immunopathology, Vol. 76, No. 3 PART 2, 01.01.1995.

Research output: Contribution to journalArticle

TY - JOUR

T1 - CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)

AU - Ramesh, Narayanaswamy

AU - Morio, Tomohiro

AU - Fuleihan, Ramsay

AU - Worm, Margitta

AU - Horner, Anthony

AU - Tsitsikov, Erdyni

AU - Castigli, Emanuela

AU - Geha, Raif S.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.

AB - Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.

UR - http://www.scopus.com/inward/record.url?scp=0029126425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029126425&partnerID=8YFLogxK

U2 - 10.1016/S0090-1229(95)90252-X

DO - 10.1016/S0090-1229(95)90252-X

M3 - Article

VL - 76

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 3 PART 2

ER -