Cd40 ligand/cd40 deficiency

E. Castigli, R. Fuleihan, N. Ramesh, E. Tsitsikov, A. Tsytsykova, R. S. Geha*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


CD40 is a surface antigen expressed on B cells. The C'D40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linkcd hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to lgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dcpcndent antigens but respond normally to T-independent antigens.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalInternational archives of allergy and immunology
Issue number1-3
StatePublished - 1995


  • CD40
  • CD40 knockout
  • CD40 ligand
  • HIGMX-1
  • Isotype switching

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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