Cd40 ligand/cd40 deficiency

E. Castigli, R. Fuleihan, N. Ramesh, E. Tsitsikov, A. Tsytsykova, R. S. Geha*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

CD40 is a surface antigen expressed on B cells. The C'D40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linkcd hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to lgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dcpcndent antigens but respond normally to T-independent antigens.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalInternational archives of allergy and immunology
Volume107
Issue number1-3
DOIs
StatePublished - Jan 1 1995

Fingerprint

CD40 Ligand
Immunoglobulin Class Switching
Ligands
Type 1 Hyper-IgM Immunodeficiency Syndrome
T Independent Antigens
T-Lymphocytes
Viral Tumor Antigens
Surface Antigens
Immunoglobulin A
Immunoglobulin E
Genes
Immunoglobulin M
B-Lymphocytes
Antigens

Keywords

  • CD40
  • CD40 knockout
  • CD40 ligand
  • HIGMX-1
  • Isotype switching

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Castigli, E., Fuleihan, R., Ramesh, N., Tsitsikov, E., Tsytsykova, A., & Geha, R. S. (1995). Cd40 ligand/cd40 deficiency. International archives of allergy and immunology, 107(1-3), 37-39. https://doi.org/10.1159/000236923
Castigli, E. ; Fuleihan, R. ; Ramesh, N. ; Tsitsikov, E. ; Tsytsykova, A. ; Geha, R. S. / Cd40 ligand/cd40 deficiency. In: International archives of allergy and immunology. 1995 ; Vol. 107, No. 1-3. pp. 37-39.
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Castigli, E, Fuleihan, R, Ramesh, N, Tsitsikov, E, Tsytsykova, A & Geha, RS 1995, 'Cd40 ligand/cd40 deficiency', International archives of allergy and immunology, vol. 107, no. 1-3, pp. 37-39. https://doi.org/10.1159/000236923

Cd40 ligand/cd40 deficiency. / Castigli, E.; Fuleihan, R.; Ramesh, N.; Tsitsikov, E.; Tsytsykova, A.; Geha, R. S.

In: International archives of allergy and immunology, Vol. 107, No. 1-3, 01.01.1995, p. 37-39.

Research output: Contribution to journalArticle

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T1 - Cd40 ligand/cd40 deficiency

AU - Castigli, E.

AU - Fuleihan, R.

AU - Ramesh, N.

AU - Tsitsikov, E.

AU - Tsytsykova, A.

AU - Geha, R. S.

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AB - CD40 is a surface antigen expressed on B cells. The C'D40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linkcd hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to lgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dcpcndent antigens but respond normally to T-independent antigens.

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KW - CD40 ligand

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KW - Isotype switching

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Castigli E, Fuleihan R, Ramesh N, Tsitsikov E, Tsytsykova A, Geha RS. Cd40 ligand/cd40 deficiency. International archives of allergy and immunology. 1995 Jan 1;107(1-3):37-39. https://doi.org/10.1159/000236923