Cd40 ligand/cd40 deficiency

E. Castigli; R. Fuleihan; N. Ramesh; E. Tsitsikov; A. Tsytsykova; R. S. Geha

doi:10.1159/000236923

Cd40 ligand/cd40 deficiency

E. Castigli, R. Fuleihan, N. Ramesh, E. Tsitsikov, A. Tsytsykova, R. S. Geha^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

CD40 is a surface antigen expressed on B cells. The C'D40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linkcd hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to lgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dcpcndent antigens but respond normally to T-independent antigens.

Original language	English (US)
Pages (from-to)	37-39
Number of pages	3
Journal	International archives of allergy and immunology
Volume	107
Issue number	1-3
DOIs	https://doi.org/10.1159/000236923
State	Published - 1995

Keywords

CD40
CD40 knockout
CD40 ligand
HIGMX-1
Isotype switching

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1159/000236923

Cite this

@article{3364f0b2ba154b93944d62819aa0c1b7,

title = "Cd40 ligand/cd40 deficiency",

abstract = "CD40 is a surface antigen expressed on B cells. The C'D40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linkcd hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to lgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dcpcndent antigens but respond normally to T-independent antigens.",

keywords = "CD40, CD40 knockout, CD40 ligand, HIGMX-1, Isotype switching",

author = "E. Castigli and R. Fuleihan and N. Ramesh and E. Tsitsikov and A. Tsytsykova and Geha, {R. S.}",

year = "1995",

doi = "10.1159/000236923",

language = "English (US)",

volume = "107",

pages = "37--39",

journal = "International archives of allergy and immunology",

issn = "1018-2438",

publisher = "S. Karger AG",

number = "1-3",

}

TY - JOUR

T1 - Cd40 ligand/cd40 deficiency

AU - Castigli, E.

AU - Fuleihan, R.

AU - Ramesh, N.

AU - Tsitsikov, E.

AU - Tsytsykova, A.

AU - Geha, R. S.

PY - 1995

Y1 - 1995

N2 - CD40 is a surface antigen expressed on B cells. The C'D40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linkcd hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to lgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dcpcndent antigens but respond normally to T-independent antigens.

AB - CD40 is a surface antigen expressed on B cells. The C'D40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linkcd hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to lgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dcpcndent antigens but respond normally to T-independent antigens.

KW - CD40

KW - CD40 knockout

KW - CD40 ligand

KW - HIGMX-1

KW - Isotype switching

UR - http://www.scopus.com/inward/record.url?scp=0029010457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029010457&partnerID=8YFLogxK

U2 - 10.1159/000236923

DO - 10.1159/000236923

M3 - Article

C2 - 7542090

AN - SCOPUS:0029010457

SN - 1018-2438

VL - 107

SP - 37

EP - 39

JO - International archives of allergy and immunology

JF - International archives of allergy and immunology

IS - 1-3

ER -

Cd40 ligand/cd40 deficiency

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this