CD5+ B cells are decreased in peripheral blood of patients with Crohn's disease

Garry A. Neil*, Robert W. Summers, Beth A. Cheyne, Carol Capenter, Wen Li Huang, Geoffrey S. Kansas, Thomas J. Waldschmidt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

B cells bearing the CD5 surface marker comprise a substantial minority of the circulating lymphocyte population in healthy individuals. These recently described cells have been implicated in T-independent humoral responses, immunoregulation, and autoimmunity. We undertook to enumerate circulating CD5+ B cells by three-color fluorescence activated flow cytometry in 28 patients with Crohn's disease (CD). None of the CD patients were using immunosuppressive medication. The CD patients were subdivided into "inactive" and "active" groups based upon their Crohn's disease activity index (CDAI). Thirty-two normal subjects served as a control population. The percentage of CD19+ B cells was significantly reduced in both active and inactive CD patients as compared with normal controls (P≤0.01). CD5+ B cells were likewise found to be significantly decreased in both inactive and active CD patients (P≤0.01) as compared with normal controls. The proportion of CD5+ B cells was significantly lower in the peripheral blood of active as compared with inactive CD patients (P≤0.05). The finding that CD5+ B cells are reduced in CD may provide an important clue to immunological dysfunction in inflammatory bowel disease and merits further study.

Original languageEnglish (US)
Pages (from-to)1390-1395
Number of pages6
JournalDigestive Diseases and Sciences
Volume37
Issue number9
DOIs
StatePublished - Sep 1 1992

Keywords

  • B cells
  • CD5 surface marker
  • Crohn's disease

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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