CD8 + T cells sabotage their own memory potential through IFN-γ-dependent modification of the IL-12/IL-15 receptor a axis on dendritic cells

Frederick J. Kohlhapp, Andrew Zloza, Jeremy A. O'Sullivan, Tamson V. Moore, Andrew T. Lacek, Michael C. Jagoda, James McCracken, David J. Cole, José A. Guevara-Patiño*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

CD8 + T cell responses have been shown to be regulated by dendritic cells (DCs) and CD4 + T cells, leading to the tenet that CD8 + T cells play a passive role in their own differentiation. In contrast, by using a DNA vaccination model, to separate the events of vaccination from those of CD8 + T cell priming, we demonstrate that CD8 + T cells, themselves, actively limit their own memory potential through CD8 + T cell-derived IFN-γ-dependent modification of the IL-12/IL-15Ra axis on DCs. Such CD8 + T cell-driven cytokine alterations result in increased T-bet and decreased Bcl-2 expression, and thus decreased memory progenitor formation. These results identify an unrecognized role for CD8 + T cells in the regulation of their own effector differentiation fate and a previously uncharacterized relationship between the balance of inflammation and memory formation.

Original languageEnglish (US)
Pages (from-to)3639-3647
Number of pages9
JournalJournal of Immunology
Volume188
Issue number8
DOIs
StatePublished - Apr 15 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Kohlhapp, F. J., Zloza, A., O&apos;Sullivan, J. A., Moore, T. V., Lacek, A. T., Jagoda, M. C., McCracken, J., Cole, D. J., & Guevara-Patiño, J. A. (2012). CD8 + T cells sabotage their own memory potential through IFN-γ-dependent modification of the IL-12/IL-15 receptor a axis on dendritic cells. Journal of Immunology, 188(8), 3639-3647. https://doi.org/10.4049/jimmunol.1101580