CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease

Timothy J. Brown, Susan E. Crawford, Mona L. Cornwall, Francesca Garcia, Stanford T. Shulman, Anne H. Rowley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

176 Scopus citations

Abstract

The pathogenesis of coronary arterial inflammation in acute Kawasaki disease (KD) is unclear. To test the hypothesis that the KD vascular lesion is an activated T lymphocyte-dependent process, immunohistochemical studies were done on coronary artery aneurysms from 8 fatal acute KD cases by using antibodies to CD45RO (activated or memory T lymphocyte), CD8 (cytotoxic T lymphocyte), CD4 (helper T lymphocyte), HAM56(macrophage), and CD20 (B lymphocyte). Acute KD coronary arteritis was characterized by transmural infiltration of CD45RO T lymphocytes with CD8 T lymphocytes predominating over CD4 T lymphocytes. Macrophages were present primarily in the adventitial layer; B lymphocytes were notably absent. These data lend support to the hypotheses that KD results from infection with an intracellular pathogen, such as a virus, whose antigens are presented by major histocompatibility complex class I molecules, and that CD8 T lymphocytes and macrophages are important in the pathogenesis of KD coronary aneurysms.

Original languageEnglish (US)
Pages (from-to)940-943
Number of pages4
JournalJournal of Infectious Diseases
Volume184
Issue number7
DOIs
StatePublished - Oct 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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