TY - JOUR
T1 - CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease
AU - Brown, Timothy J.
AU - Crawford, Susan E.
AU - Cornwall, Mona L.
AU - Garcia, Francesca
AU - Shulman, Stanford T.
AU - Rowley, Anne H.
N1 - Funding Information:
Received 12 April 2001; revised 8 June 2001; electronically published 22 August 2001. Presented in part: annual meeting of the Pediatric Academic Societies, Baltimore, April 2001 (abstract 70). This study was approved by the Children’s Memorial Hospital institutional review board. Financial support: National Institutes of Health (HL-63771 to A.H.R.); Kawasaki Disease Research Fund of Children’s Memorial Hospital. Reprints or correspondence: Dr. Anne Rowley, Northwestern University Medical School, Pediatrics W140, Ward 12-204, 303 E. Chicago Ave., Chicago, IL 60611 (a-rowley@northwestern.edu).
PY - 2001/10/1
Y1 - 2001/10/1
N2 - The pathogenesis of coronary arterial inflammation in acute Kawasaki disease (KD) is unclear. To test the hypothesis that the KD vascular lesion is an activated T lymphocyte-dependent process, immunohistochemical studies were done on coronary artery aneurysms from 8 fatal acute KD cases by using antibodies to CD45RO (activated or memory T lymphocyte), CD8 (cytotoxic T lymphocyte), CD4 (helper T lymphocyte), HAM56(macrophage), and CD20 (B lymphocyte). Acute KD coronary arteritis was characterized by transmural infiltration of CD45RO T lymphocytes with CD8 T lymphocytes predominating over CD4 T lymphocytes. Macrophages were present primarily in the adventitial layer; B lymphocytes were notably absent. These data lend support to the hypotheses that KD results from infection with an intracellular pathogen, such as a virus, whose antigens are presented by major histocompatibility complex class I molecules, and that CD8 T lymphocytes and macrophages are important in the pathogenesis of KD coronary aneurysms.
AB - The pathogenesis of coronary arterial inflammation in acute Kawasaki disease (KD) is unclear. To test the hypothesis that the KD vascular lesion is an activated T lymphocyte-dependent process, immunohistochemical studies were done on coronary artery aneurysms from 8 fatal acute KD cases by using antibodies to CD45RO (activated or memory T lymphocyte), CD8 (cytotoxic T lymphocyte), CD4 (helper T lymphocyte), HAM56(macrophage), and CD20 (B lymphocyte). Acute KD coronary arteritis was characterized by transmural infiltration of CD45RO T lymphocytes with CD8 T lymphocytes predominating over CD4 T lymphocytes. Macrophages were present primarily in the adventitial layer; B lymphocytes were notably absent. These data lend support to the hypotheses that KD results from infection with an intracellular pathogen, such as a virus, whose antigens are presented by major histocompatibility complex class I molecules, and that CD8 T lymphocytes and macrophages are important in the pathogenesis of KD coronary aneurysms.
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U2 - 10.1086/323155
DO - 10.1086/323155
M3 - Article
C2 - 11528596
AN - SCOPUS:0035479240
VL - 184
SP - 940
EP - 943
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 7
ER -
