CD86 and β2-adrenergic receptor stimulation regulate B-cell activity cooperatively

Joseph R. Podojil, Virginia M. Sanders*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

IgG1 functions to neutralize and clear foreign antigens, such as extracellular bacteria. Therefore, it is important to understand the multiple mechanisms by which the level of IgG1 is regulated to maintain immune system and host homeostasis. Recent data show that the level of IgG1 produced by a B cell is increased following CD86 and β2-adrenergic receptor (β2AR) stimulation, through increased expression of the transcription factor Oct-2 and its coactivator OCA-B (Oct coactivator from B cells), respectively. This finding suggests that signaling pathways that are activated by an immunoreceptor (CD86) and a neuroreceptor (β2AR) converge to regulate the IgG1 response.

Original languageEnglish (US)
Pages (from-to)180-185
Number of pages6
JournalTrends in Immunology
Volume26
Issue number4
DOIs
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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