CD8+ granulomatous cutaneous T-cell lymphoma: A potential association with immunodeficiency

Bryan Gammon*, Alistair Robson, Janyana Deonizio, Lisa Arkin, Joan Guitart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background Granulomatous cutaneous T-cell lymphoma (G-CTCL) is a rarely encountered entity. Most G-CTCL is CD4+, with granulomatous mycosis fungoides representing the vast majority of cases. Because of the rarity of CD8+ G-CTCL, there is a paucity of data regarding the clinicopathologic features and expected course. Objective To describe the clinical and histopathologic features of G-CTCL. Methods This is a retrospective review of collected cases. Results We present 4 cases of CD8+ G-CTCL. Patients presented with papules and nodules on the trunk and extremities without antecedent patch or plaque disease. In all cases, biopsy specimens were obtained, and these revealed a dense granulomatous infiltrate accompanied by an atypical lymphoid infiltrate of CD8+ T cells. T-cell clonality studies were positive in 3 of 4 cases. Staging was negative for nodal involvement, but lung granulomas were seen in all cases. In all 4 cases, the patient's medical history was significant for immunodeficiency, either primary or iatrogenic. All 4 patients had slowly progressive disease. Limitations This is a small retrospective case series. Conclusions CD8+ G-CTCL appears to be associated with immunodeficiency. The finding of a CD8+ G-CTCL should prompt an evaluation for underlying immunodeficiency. Additional studies are required to validate these conclusions.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Sep 2014


  • X-linked agammaglobulinemia
  • common variable immunodeficiency
  • cutaneous T-cell lymphoma
  • cytotoxic
  • granulomatous
  • immunodeficiency
  • mycosis fungoides

ASJC Scopus subject areas

  • Dermatology


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