CD95 (APO-1/Fas)-associating signalling proteins

Marcus E. Peter*, Frank C. Kischkel, Stefan Hellbardt, Arul M. Chinnaiyan, Peter H. Krammer, Vishva M. Dixit

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations

Abstract

The CD95 (APO-1/Fas) receptor has attracted great interest in recent years because it transduces an apoptotic signal in a variety of different tissues. CD95 belongs to the NGF/TNF-receptor superfamily, members of which need to be trimerized by specific protein ligands in order to generate a signal. This review focuses on recent advances in the understanding of the proximal signal transduction mechanism of CD95. The cloning of numerous proteins that interact with CD95 and other members of this receptor family and the in vivo identification of several proteins that associate with CD95 in a ligand-dependent fashion opens the way to delineate the death pathway and to explain crosstalk among these receptors on a molecular basis.

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalCell Death and Differentiation
Volume3
Issue number2
StatePublished - Jan 1 1996

Keywords

  • CAP proteins
  • CD95 (APO-1/Fas)
  • DISC
  • Signal transduction
  • TNF-R family

ASJC Scopus subject areas

  • Cell Biology

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