CD95 (APO-1/Fas)-associating signalling proteins

Marcus E. Peter; Frank C. Kischkel; Stefan Hellbardt; Arul M. Chinnaiyan; Peter H. Krammer; Vishva M. Dixit

CD95 (APO-1/Fas)-associating signalling proteins

Marcus E. Peter^*, Frank C. Kischkel, Stefan Hellbardt, Arul M. Chinnaiyan, Peter H. Krammer, Vishva M. Dixit

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

The CD95 (APO-1/Fas) receptor has attracted great interest in recent years because it transduces an apoptotic signal in a variety of different tissues. CD95 belongs to the NGF/TNF-receptor superfamily, members of which need to be trimerized by specific protein ligands in order to generate a signal. This review focuses on recent advances in the understanding of the proximal signal transduction mechanism of CD95. The cloning of numerous proteins that interact with CD95 and other members of this receptor family and the in vivo identification of several proteins that associate with CD95 in a ligand-dependent fashion opens the way to delineate the death pathway and to explain crosstalk among these receptors on a molecular basis.

Original language	English (US)
Pages (from-to)	161-170
Number of pages	10
Journal	Cell Death and Differentiation
Volume	3
Issue number	2
State	Published - Jan 1 1996

Keywords

CAP proteins
CD95 (APO-1/Fas)
DISC
Signal transduction
TNF-R family

ASJC Scopus subject areas

Cell Biology

Cite this

@article{ef82779058054921a50dcd2be41e5e24,

title = "CD95 (APO-1/Fas)-associating signalling proteins",

abstract = "The CD95 (APO-1/Fas) receptor has attracted great interest in recent years because it transduces an apoptotic signal in a variety of different tissues. CD95 belongs to the NGF/TNF-receptor superfamily, members of which need to be trimerized by specific protein ligands in order to generate a signal. This review focuses on recent advances in the understanding of the proximal signal transduction mechanism of CD95. The cloning of numerous proteins that interact with CD95 and other members of this receptor family and the in vivo identification of several proteins that associate with CD95 in a ligand-dependent fashion opens the way to delineate the death pathway and to explain crosstalk among these receptors on a molecular basis.",

keywords = "CAP proteins, CD95 (APO-1/Fas), DISC, Signal transduction, TNF-R family",

author = "Peter, {Marcus E.} and Kischkel, {Frank C.} and Stefan Hellbardt and Chinnaiyan, {Arul M.} and Krammer, {Peter H.} and Dixit, {Vishva M.}",

year = "1996",

month = jan,

day = "1",

language = "English (US)",

volume = "3",

pages = "161--170",

journal = "Cell Death and Differentiation",

issn = "1350-9047",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - CD95 (APO-1/Fas)-associating signalling proteins

AU - Peter, Marcus E.

AU - Kischkel, Frank C.

AU - Hellbardt, Stefan

AU - Chinnaiyan, Arul M.

AU - Krammer, Peter H.

AU - Dixit, Vishva M.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The CD95 (APO-1/Fas) receptor has attracted great interest in recent years because it transduces an apoptotic signal in a variety of different tissues. CD95 belongs to the NGF/TNF-receptor superfamily, members of which need to be trimerized by specific protein ligands in order to generate a signal. This review focuses on recent advances in the understanding of the proximal signal transduction mechanism of CD95. The cloning of numerous proteins that interact with CD95 and other members of this receptor family and the in vivo identification of several proteins that associate with CD95 in a ligand-dependent fashion opens the way to delineate the death pathway and to explain crosstalk among these receptors on a molecular basis.

AB - The CD95 (APO-1/Fas) receptor has attracted great interest in recent years because it transduces an apoptotic signal in a variety of different tissues. CD95 belongs to the NGF/TNF-receptor superfamily, members of which need to be trimerized by specific protein ligands in order to generate a signal. This review focuses on recent advances in the understanding of the proximal signal transduction mechanism of CD95. The cloning of numerous proteins that interact with CD95 and other members of this receptor family and the in vivo identification of several proteins that associate with CD95 in a ligand-dependent fashion opens the way to delineate the death pathway and to explain crosstalk among these receptors on a molecular basis.

KW - CAP proteins

KW - CD95 (APO-1/Fas)

KW - DISC

KW - Signal transduction

KW - TNF-R family

UR - http://www.scopus.com/inward/record.url?scp=0029933918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029933918&partnerID=8YFLogxK

M3 - Review article

C2 - 17180078

AN - SCOPUS:0029933918

SN - 1350-9047

VL - 3

SP - 161

EP - 170

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 2

ER -

CD95 (APO-1/Fas)-associating signalling proteins

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this