CDC25A phosphatase: A rate-limiting oncogene that determines genomic stability

Dipankar Ray, Hiroaki Kiyokawa*

*Corresponding author for this work

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.

Original languageEnglish (US)
Pages (from-to)1251-1253
Number of pages3
JournalCancer Research
Volume68
Issue number5
DOIs
StatePublished - Mar 1 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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