Cdk6-dependent regulation of G1 length controls adult neurogenesis

Pierre Beukelaers, Renaud Vandenbosch, Nicolas Caron, Laurent Nguyen, Shibeshih Belachew, Gustave Moonen, Hiroaki Kiyokawa, Mariano Barbacid, David Santamaria, Brigitte Malgrange*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The presence of neurogenic precursors in the adult mammalian brain is now widely accepted, but the mechanisms coupling their proliferation with the onset of neuronal differentiation remain unknown. Here, we unravel the major contribution of the G1 regulator cyclin-dependent kinase 6 (Cdk6) to adult neurogenesis. We found that Cdk6 was essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Specifically, Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G1 phase duration, reducing concomitantly the production of newborn neurons. Altogether, our data support G1 length as an essential regulator of the switch between proliferation and neuronal differentiation in the adult brain and Cdk6 as one intrinsic key molecular regulator of this process.

Original languageEnglish (US)
Pages (from-to)713-724
Number of pages12
JournalStem Cells
Volume29
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Adult neurogenesis
  • Cell cycle
  • Cyclin-dependent kinase
  • Dentate gyrus
  • G length
  • Subventricular zone

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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