cDNA approaches to isolation of the mouse mutant weaver gene

M. E. Hodes*, S. R. Dlouhy, J. J. Wei, Y. Wang, L. Sangameswaran, V. Lazar, L. C. Triarhou, B. Ghetti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The mouse autosomal recessive mutant gene weaver (wv) results in abnormalities in cerebellum, substantia nigra and testis. Although a subtracted cDNA library prepared by removing P31 (wv/wv) sequences from a P1 (wv/+) library should contain mainly nonrepetitive neonatal sequences, unfortunately, repetitive sequences still appear during screening. Two clones, one repetitive, the other not, are used to illustrate the problems encountered in attempting to isolate the weaver gene from a subtracted cDNA library.

Original languageEnglish (US)
Pages (from-to)1359-1362
Number of pages4
JournalNeurochemical Research
Issue number11
StatePublished - Nov 1994


  • Weaver
  • granule cells
  • mutant mice
  • sequence, in situ hybridization

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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