Ceftazidime versus ceftazidime plus tobramycin in febrile neutropenic children

R. F. Jacobs*, D. L. Becton, M. Kletzel, T. S. Vats, K. A. Pappa, S. Chaudhary

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Although the effectiveness of antibiotic monotherapy in febrile neutropenic patients remains unproven, ceftazidime has been shown previously to be effective monotherapy for the empiric treatment of selective patients. The efficacy and safety of ceftazidime versus ceftazidime plus tobramycin was evaluated in the treatment of febrile children (range 8 months to 18 years) with neutropenia secondary to cancer chemotherapeutic agents. Of the evaluable 89 patients, 45 received ceftazidime and 44 received ceftazidime plus tobramycin for 5 to 10 days. At the end of therapy, 30 (67%) of the 45 ceftazidime-treated patients were clinically cured compared with 38 (86%) of 44 combination-treated patients. Thirteen (29%) of the patients treated with ceftazidime failed to respond clinically to treatment, versus four (9%) of the patients treated with ceftazidime/tobramycin (p=0.046). This study suggests that ceftazidime as monotherapy in febrile neutropenic children may be inferior to combination therapy for optimal clinical response in these patients.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalInfection
Volume21
Issue number4
DOIs
StatePublished - Jul 1993

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Ceftazidime versus ceftazidime plus tobramycin in febrile neutropenic children'. Together they form a unique fingerprint.

  • Cite this

    Jacobs, R. F., Becton, D. L., Kletzel, M., Vats, T. S., Pappa, K. A., & Chaudhary, S. (1993). Ceftazidime versus ceftazidime plus tobramycin in febrile neutropenic children. Infection, 21(4), 223-228. https://doi.org/10.1007/BF01728894