Ceftriaxone therapy of group b streptococcal bacteraemia and meningitis in infant rats

Dietra Deleplane*, Ram Yogev, Stanford T. Shulman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The efficacy of ceftriaxone against group B streptococci was studied in vitro and in vivo with an infant rat model of group B streptococci bacteraemia and meningitis. Twenty-four strains demonstrated minimal inhibitory concentrations of ceftriaxone of 0.05-0.1 mg/1 and minimal bactericidal concentrations of 0.1-0.4 mg/1. Four strains were selected to induce bacteraemia and meningitis in infant rats by intraperitoneal inoculation. All 45 bacteraemic animals with or without meningitis that were treated with ceftriaxone 2 mg/kg/dose every eight hours for five doses survived, while all 12 control animals died (P≤000l). When recultured 54 h after the last dose of ceftriaxone, both CSF and blood remained sterile in all treated animals. These results indicate group B streptococci to be sensitive to ceftriazone in vitro and that, in the low dosage used, ceftriaxone effectively eradicates group B streptococcal bacteraemia and meningitis in infant rats.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Ceftriaxone therapy of group b streptococcal bacteraemia and meningitis in infant rats'. Together they form a unique fingerprint.

Cite this