@article{852d27bf433b4dc6bb468c0818580c2f,
title = "Celastrol-loaded PEG-: B -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis",
abstract = " In this work, the hydrophobic small molecule NF-κB inhibitor celastrol was loaded into poly(ethylene glycol)-b-poly(propylene sulfide) (PEG-b-PPS) micelles. PEG-b-PPS micelles demonstrated high loading efficiency, low polydispersity, and no morphological changes upon loading with celastrol. Encapsulation of celastrol within these nanocarriers significantly reduced cytotoxicity compared to free celastrol, while simultaneously expanding the lower concentration range for effective inhibition of NF-κB signaling by nearly 50000-fold. Furthermore, celastrol-loaded micelles successfully reduced TNF-α secretion after LPS stimulation of RAW 264.7 cells and reduced the number of neutrophils and inflammatory monocytes within atherosclerotic plaques of ldlr -/- mice. This reduction in inflammatory cells was matched by a reduction in plaque area, suggesting that celastrol-loaded nanocarriers may serve as an anti-inflammatory treatment for atherosclerosis. ",
author = "Allen, {Sean D.} and Liu, {Yu Gang} and Taehyeung Kim and Sharan Bobbala and Sijia Yi and Xiaohan Zhang and Jaehyuk Choi and Scott, {Evan A.}",
note = "Funding Information: We would like to acknowledge the aid Dr Catherine Reardon provided in the form of training for the recovery of aorta from atherosclerotic mice. This work was supported by the Northwestern University – Flow Cytometry Core Facility supported by Cancer Center Support Grant (NCI CA060553). This work made use of the Keck-II facility of Northwestern University{\textquoteright}s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205); the MRSEC program (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; and the State of Illinois, through the IIN. Histology services were provided by the Northwestern University Research Histology and Phenotyping Laboratory which is supported by NCI P30-CA060553 awarded to the Robert H Lurie Comprehensive Cancer Center. This research was supported by the National Science Foundation grant 1453576 and the National Institutes of Health Director{\textquoteright}s New Innovator Award no. 1DP2HL132390-01. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
month = feb,
doi = "10.1039/c8bm01224e",
language = "English (US)",
volume = "7",
pages = "657--668",
journal = "Biomaterials Science",
issn = "2047-4830",
publisher = "Royal Society of Chemistry",
number = "2",
}