Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina

Jos Käfer*, Takashi Hayashi, Athanasius F.M. Marée, Richard W. Carthew, François Graner

*Corresponding author for this work

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Because of the resemblance of many epithelial tissues to densely packed soap bubbles, it has been suggested that surface minimization, which drives soap bubble packing, could be governing cell packing as well. We test this by modeling the shape of the cells in a Drosophila retina ommatidium. We use the observed configurations and shapes in wild-type flies, as well as in flies with different numbers of cells per ommatidia, and mutants with cells where Eor N-cadherin is either deleted or misexpressed. We find that surface minimization is insufficient to model the experimentally observed shapes and packing of the cells based on their cadherin expression. We then consider a model in which adhesion leads to a surface increase, balanced by cell cortex contraction. Using the experimentally observed distributions of E- and N-cadherin, we simulate the packing and cell shapes in the wild-type eye. Furthermore, by changing only the corresponding parameters, this model can describe the mutants with different numbers of cells or changes in cadherin expression.

Original languageEnglish (US)
Pages (from-to)18549-18554
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number47
DOIs
StatePublished - Nov 20 2007

Keywords

  • Cell shape
  • Cellular Potts model
  • Surface mechanics

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina'. Together they form a unique fingerprint.

  • Cite this