Cell adhesion molecules and their involvement in autism spectrum disorder

Haihong Ye, Jianghong Liu, Jane Y. Wu

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormalities in social interaction, language development and behavior. Recent genetic studies demonstrate that alterations in synaptic genes including those encoding cell adhesion molecules and their interaction partners play important roles in the pathogenesis of ASD. Systematic analyses of different cell adhesion molecule genes will help elucidate their normal functions and regulatory mechanisms in the establishment and maintenance of normal neural circuits and uncover genetic aberrations contributing to ASD.

Original languageEnglish (US)
Pages (from-to)62-71
Number of pages10
JournalNeuroSignals
Volume18
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • Autism spectrum disorder
  • Cell adhesion molecules
  • Neural development
  • Neurexins

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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