Abstract
Human artificial chromosomes (HACs) are a potentially powerful technique for genomic engineering, but their use is limited by the repetitive centromeric alpha-satellite DNA needed to form a centromere. A new study presents a method to induce HAC centromere formation on non-repetitive templates through sequence-directed CENP-A nucleosome seeding.
Original language | English (US) |
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Pages (from-to) | R1194-R1196 |
Journal | Current Biology |
Volume | 29 |
Issue number | 22 |
DOIs | |
State | Published - Nov 18 2019 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences