Cell Biology: Hacking Alpha Satellites out of the HAC

Alexander B. Willis, Daniel R. Foltz*

*Corresponding author for this work

Research output: Contribution to journalShort survey

Abstract

Human artificial chromosomes (HACs) are a potentially powerful technique for genomic engineering, but their use is limited by the repetitive centromeric alpha-satellite DNA needed to form a centromere. A new study presents a method to induce HAC centromere formation on non-repetitive templates through sequence-directed CENP-A nucleosome seeding.

Original languageEnglish (US)
Pages (from-to)R1194-R1196
JournalCurrent Biology
Volume29
Issue number22
DOIs
StatePublished - Nov 18 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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