Cell cycle exit upon myogenic differentiation

Kenneth Walsh*, Harris Perlman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

248 Scopus citations

Abstract

Myogenic precursor cells withdraw irreversibly from the cell cycle as they differentiate into mature myotubes. Cell cycle exit occurs early during the differentiation program and is required for normal expression of the contractile phenotype. Differentiated myocytes also display a decreased propensity to undergo apoptotic cell death. The upregulation of the cyclin-dependent kinase inhibitor p21 and the dephosphorylation of retinoblastoma protein (pRb) appear to be critical regulatory events for the establishment of both the postmitotic and apoptosis-resistant states. The coordinated regulation of cell proliferation and death provides the developing embryo with a mechanism for controlling muscle mass and thereby the size of individual motor units.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume7
Issue number5
DOIs
StatePublished - Oct 1997

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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