Cell cycle kinetic studies in human cancers: Development of three DNA-specific labels in three decades

A. Raza*, J. Bokhari, N. Yousuf, A. Mehdi, C. Mazewski, S. Khan, V. Baker, B. Lampkin

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Controversy has epitomized the prognostic and clinical significance accorded to cell cycle kinetic studies in neoplastic diseases. Recent introduction of monoclonal antibodies to thymidine analogues such as iododeoxyuridine and bromodeoxyuridine has unveiled a spectacular new area of research. Large numbers of patients with liquid and solid tumors have been interrogated by introducing iododeoxyuridine and bromodeoxyuridine as DNA-specific probes in vivo. Further in vitro incubation of S-phase cells already double-labeled in vivo with tritiated thymidine has added a whole new dimension to the kinds of questions that can now be addressed with alacrity. Time is rapidly approaching when this information will be available in a prompt enough fashion to be useful for planning therapeutic strategies. Reviewed are the salient features of the rapid progress achieved in the last decade in this exciting discipline.

Original languageEnglish (US)
Pages (from-to)873-879
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Volume115
Issue number9
StatePublished - 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Fingerprint Dive into the research topics of 'Cell cycle kinetic studies in human cancers: Development of three DNA-specific labels in three decades'. Together they form a unique fingerprint.

  • Cite this

    Raza, A., Bokhari, J., Yousuf, N., Mehdi, A., Mazewski, C., Khan, S., Baker, V., & Lampkin, B. (1991). Cell cycle kinetic studies in human cancers: Development of three DNA-specific labels in three decades. Archives of Pathology and Laboratory Medicine, 115(9), 873-879.