TY - JOUR
T1 - Cell-free biology
T2 - Exploiting the interface between synthetic biology and synthetic chemistry
AU - Harris, D. Calvin
AU - Jewett, Michael C.
N1 - Funding Information:
The authors would like to thank Rachel K. O’Reilly for her advice and discussions. We also gratefully acknowledge funding from the National Institutes of Health (Grant Number R00GM081450 ), the National Academies Keck Futures Initiative (Grant Number NAFKI-SB5 ), the National Science Foundation (Grant Number MCB-0943393 ), the Office of Naval Research (Grant Number N00014-11-1-0363 ), the DARPA YFA Program (Grant Number N66001-11-1-4137 ), and the ARMY Research Office (Grant Number W911NF-11-1-044 ).
PY - 2012/10
Y1 - 2012/10
N2 - Just as synthetic organic chemistry once revolutionized the ability of chemists to build molecules (including those that did not exist in nature) following a basic set of design rules, cell-free synthetic biology is beginning to provide an improved toolbox and faster process for not only harnessing but also expanding the chemistry of life. At the interface between chemistry and biology, research in cell-free synthetic systems is proceeding in two different directions: using synthetic biology for synthetic chemistry and using synthetic chemistry to reprogram or mimic biology. In the coming years, the impact of advances inspired by these approaches will make possible the synthesis of nonbiological polymers having new backbone compositions, new chemical properties, new structures, and new functions.
AB - Just as synthetic organic chemistry once revolutionized the ability of chemists to build molecules (including those that did not exist in nature) following a basic set of design rules, cell-free synthetic biology is beginning to provide an improved toolbox and faster process for not only harnessing but also expanding the chemistry of life. At the interface between chemistry and biology, research in cell-free synthetic systems is proceeding in two different directions: using synthetic biology for synthetic chemistry and using synthetic chemistry to reprogram or mimic biology. In the coming years, the impact of advances inspired by these approaches will make possible the synthesis of nonbiological polymers having new backbone compositions, new chemical properties, new structures, and new functions.
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U2 - 10.1016/j.copbio.2012.02.002
DO - 10.1016/j.copbio.2012.02.002
M3 - Review article
C2 - 22483202
AN - SCOPUS:84867226844
VL - 23
SP - 672
EP - 678
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
IS - 5
ER -