Cell-free biomanufacturing

Bradley C. Bundy, J. Porter Hunt, Michael C. Jewett, James R. Swartz, David W. Wood, Douglas D. Frey, Govind Rao

Research output: Contribution to journalReview article

13 Scopus citations


Since its early development and use to decipher the genetic code, in vitro or ‘cell-free’ systems have been used as an important research tool to understand biochemical mechanisms and metabolic pathways. More recently, due to important engineering advances the technology is rapidly becoming a biomanufacturing platform for protein therapeutics, vaccines, enzyme biocatalysts, fuels, and commodity chemicals. Here we report recent applications and advances in the cell-free biomanufacturing field and the potential of this emerging approach.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalCurrent Opinion in Chemical Engineering
StatePublished - Dec 2018

ASJC Scopus subject areas

  • Energy(all)

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    Bundy, B. C., Hunt, J. P., Jewett, M. C., Swartz, J. R., Wood, D. W., Frey, D. D., & Rao, G. (2018). Cell-free biomanufacturing. Current Opinion in Chemical Engineering, 22, 177-183. https://doi.org/10.1016/j.coche.2018.10.003