Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation

Biochemistry, Genetics and Molecular Biology

• Protein Catabolism 100%
• Gene Activation 100%
• down Regulation 100%
• Mesenchymal-Epithelial Transition 50%
• Smad3 Protein 50%
• mRNA Stability 25%
• Proteasome Inhibitor 25%
• Promoter Region 25%
• SMAD (Protein) 25%
• Biological Functions 25%
• Biological Phenomena and Functions Concerning the Entire Organism 25%
• Upregulation 25%
• Ubiquitination 25%
• Mesangial Cell 25%
• Actin 25%
• Proteasome 25%
• Ubiquitin 25%
• Messenger RNA 25%
• Cadherin 25%
• Cancer Growth Factor 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Smad3 Protein 100%
• Messenger RNA 100%
• Receptor 50%
• Kidney Fibrosis 50%
• Uvomorulin 50%
• Smooth Muscle Actin 50%
• Ureter Obstruction 50%
• Cancer Growth Factor 50%
• Smad Protein 50%
• Fibrosis 50%
• Ubiquitin 50%
• Proteasome 50%
• Proteasome Inhibitor 50%

Keyphrases

• Gene Activation 100%
• Smad3 100%
• Protein Degradation 100%
• Cell Phenotype 100%
• TGF-1 50%
• Protein Level 25%
• Smad 16%
• Epithelial-to-mesenchymal Transition 16%
• Smad3 Protein 16%
• Biological Processes 8%
• Transforming Growth Factor-β 8%
• Kidney 8%
• Smad Proteins 8%
• Promoter Activity 8%
• MRNA Expression 8%
• Protease Inhibitors 8%
• Biological Function 8%
• Ubiquitination 8%
• E-cadherin 8%
• Decreased Expression 8%
• Tight Control 8%
• Renal Fibrosis 8%
• Renal Tubular Epithelial Cells 8%
• Tubulointerstitial Fibrosis 8%
• Ubiquitin-proteasome System 8%
• Transcriptional Level 8%
• TGF Signaling 8%
• Inhibitor Treatment 8%
• MRNA Stability 8%
• Feedback Loop 8%
• α-smooth muscle Actin (α-SMA) 8%
• Smad2 8%
• SMAD4 8%
• Human Glomerular Mesangial Cells 8%
• Unilateral Ureteral Obstruction 8%