Cell therapy strategies and improvements for muscular dystrophy

Mattia Quattrocelli*, M. Cassano, S. Crippa, I. Perini, M. Sampaolesi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Understanding stem cell commitment and differentiation is a critical step towards clinical translation of cell therapies. In past few years, several cell types have been characterized and transplanted in animal models for different diseased tissues, eligible for a cell-mediated regeneration. Skeletal muscle damage is a challenge for cell- and gene-based therapeutical approaches, given the unique architecture of the tissue and the clinical relevance of acute damages or dystrophies. In this review, we will consider the regenerative potential of embryonic and somatic stem cells and the outcomes achieved on their transplantation into animal models for muscular dystrophy or acute muscle impairment.

Original languageEnglish (US)
Pages (from-to)1222-1229
Number of pages8
JournalCell Death and Differentiation
Volume17
Issue number8
DOIs
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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