TY - JOUR
T1 - Cell therapy strategies and improvements for muscular dystrophy
AU - Quattrocelli, Mattia
AU - Cassano, M.
AU - Crippa, S.
AU - Perini, I.
AU - Sampaolesi, M.
N1 - Funding Information:
Acknowledgements. We thank Paolo Luban for his support. We are particularly grateful to Guido Tettamanti and Giulio Cossu for critical reading of the paper and for helpful comments, and Shea Carter for the ms proofreading service. This work was supported by FWO Odysseus Program n. G.0907.08; Wicka Funds n. zkb8720, University of Minnesota US; the Italian Ministry of University and Scientific Research (grant n. 2005067555_003, COFIN 2006–08), the Muscular Dystrophy Association, Association Francoise contre les Myopathies, CARIPLO Funds 2007-5639 and 2008-2005.
PY - 2010/8
Y1 - 2010/8
N2 - Understanding stem cell commitment and differentiation is a critical step towards clinical translation of cell therapies. In past few years, several cell types have been characterized and transplanted in animal models for different diseased tissues, eligible for a cell-mediated regeneration. Skeletal muscle damage is a challenge for cell- and gene-based therapeutical approaches, given the unique architecture of the tissue and the clinical relevance of acute damages or dystrophies. In this review, we will consider the regenerative potential of embryonic and somatic stem cells and the outcomes achieved on their transplantation into animal models for muscular dystrophy or acute muscle impairment.
AB - Understanding stem cell commitment and differentiation is a critical step towards clinical translation of cell therapies. In past few years, several cell types have been characterized and transplanted in animal models for different diseased tissues, eligible for a cell-mediated regeneration. Skeletal muscle damage is a challenge for cell- and gene-based therapeutical approaches, given the unique architecture of the tissue and the clinical relevance of acute damages or dystrophies. In this review, we will consider the regenerative potential of embryonic and somatic stem cells and the outcomes achieved on their transplantation into animal models for muscular dystrophy or acute muscle impairment.
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U2 - 10.1038/cdd.2009.160
DO - 10.1038/cdd.2009.160
M3 - Review article
C2 - 19876070
AN - SCOPUS:77954658692
SN - 1350-9047
VL - 17
SP - 1222
EP - 1229
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
IS - 8
ER -