Cells in the bulge of the mouse telogen follicle give rise to the lower anagen follicle

C. L. Wilson, T. T. Sunb, Robert M. Lavkera*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The slow-cycling cells in the bulge of the outer root sheath may represent stem cells for the hair follicle. With each new anagen (growing) phase bulge cells would give rise to a population of transient-amplifying cells which differentiate into outer root sheath and matrix keratinocytes. The lowermost part of the telogen (resting) follicle is composed of bulge cells lying in close proximity to the dermal papilla. In the mouse the first hair follicle growth is characterized by rapid follicular neogenesis, but the second and third growth cycles follow the normal follicular growth pattern. We have examined activity of cells in the bulge at the onset of anagen (growing phase) in the third hair cycle in Senear mice, by treating animals at the end of the second telogen with colchicine to localize mitotic activity in the hair follicle. Mitoses were only seen in bulge cells during early anagen. This confirms that they proliferate transiently, solely at the onset of anagen and strongly supports the suggestion that bulge cells are the origin of the whole lower follicle in anagen.

Original languageEnglish (US)
Pages (from-to)8-11
Number of pages4
JournalSkin Pharmacology and Physiology
Volume7
Issue number1-2
DOIs
StatePublished - Jan 1 1994

Keywords

  • Anagen
  • Bulge
  • Hair follicle
  • Stem cells

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Dermatology

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